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Adherence to medication according to sex and age in the CHARM programme.

Publication ,  Journal Article
Granger, BB; Ekman, I; Granger, CB; Ostergren, J; Olofsson, B; Michelson, E; McMurray, JJV; Yusuf, S; Pfeffer, MA; Swedberg, K
Published in: Eur J Heart Fail
November 2009

AIMS: Although many patients with heart failure have incomplete adherence to prescribed medications, predisposing factors remain unclear. This analysis investigates factors associated with adherence, with particular emphasis on age and sex. METHODS AND RESULTS: A multivariable regression analysis of 7599 heart failure patients from the CHARM trial was done to evaluate factors associated with adherence. Adherence was measured as the proportion of time patients took more than 80% of study medication. The mean age was 66 years (SD 11) and 31.5% (n = 2400) were women. Women were slightly less adherent than men (87.3 vs. 89.8%, P = 0.002), even in adjusted, multivariable models (treatment, P = 0.006; placebo P = 0.004; and overall P < 0.001). However, all-cause mortality was lower in women (21.5%) than in men (25.3%) (adjusted hazard ratio, 0.77; 95% CI, 0.69-0.86; P < 0.001), but patients with a low adherence regardless of sex had a higher mortality. Age, severity of heart failure, number of medications, and smoking status were not associated with adherence. CONCLUSION: Women, particularly those <75 years of age, were less likely to be adherent in this large sample of patients with symptomatic heart failure. Understanding factors associated with adherence may provide opportunities for intervention.

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Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2009

Volume

11

Issue

11

Start / End Page

1092 / 1098

Location

England

Related Subject Headings

  • Sex Factors
  • Regression Analysis
  • Multivariate Analysis
  • Medication Adherence
  • Male
  • Humans
  • Heart Failure
  • Female
  • Cardiovascular System & Hematology
  • Aged
 

Citation

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Granger, B. B., Ekman, I., Granger, C. B., Ostergren, J., Olofsson, B., Michelson, E., … Swedberg, K. (2009). Adherence to medication according to sex and age in the CHARM programme. Eur J Heart Fail, 11(11), 1092–1098. https://doi.org/10.1093/eurjhf/hfp142
Granger, Bradi B., Inger Ekman, Christopher B. Granger, Jan Ostergren, Bertil Olofsson, Eric Michelson, John J. V. McMurray, Salim Yusuf, Marc A. Pfeffer, and Karl Swedberg. “Adherence to medication according to sex and age in the CHARM programme.Eur J Heart Fail 11, no. 11 (November 2009): 1092–98. https://doi.org/10.1093/eurjhf/hfp142.
Granger BB, Ekman I, Granger CB, Ostergren J, Olofsson B, Michelson E, et al. Adherence to medication according to sex and age in the CHARM programme. Eur J Heart Fail. 2009 Nov;11(11):1092–8.
Granger, Bradi B., et al. “Adherence to medication according to sex and age in the CHARM programme.Eur J Heart Fail, vol. 11, no. 11, Nov. 2009, pp. 1092–98. Pubmed, doi:10.1093/eurjhf/hfp142.
Granger BB, Ekman I, Granger CB, Ostergren J, Olofsson B, Michelson E, McMurray JJV, Yusuf S, Pfeffer MA, Swedberg K. Adherence to medication according to sex and age in the CHARM programme. Eur J Heart Fail. 2009 Nov;11(11):1092–1098.
Journal cover image

Published In

Eur J Heart Fail

DOI

EISSN

1879-0844

Publication Date

November 2009

Volume

11

Issue

11

Start / End Page

1092 / 1098

Location

England

Related Subject Headings

  • Sex Factors
  • Regression Analysis
  • Multivariate Analysis
  • Medication Adherence
  • Male
  • Humans
  • Heart Failure
  • Female
  • Cardiovascular System & Hematology
  • Aged