Scholars@Duke publication: BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects?

BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects?

Publication , Journal Article

Davidson, J; Dren, A; Miller, R; Manberg, P; Kilts, C; Wingfield, M

Published in: Drug Development Research

1985

Based on studies in animals and in healthy human volunteers, it was predicted that the carbazole compound BW234U would have antipsychotic effects in patients without producing concomitant extrapyramidal effects. The compound was administered to 22 inpatients with schizophrenia in an open, dose-ranging pilot study designed to assess antipsychotic effects as well as side effect profile. Clinical changes were observed on the BPRS and global improvement scales over a 4-week period. No extrapyramidal side effects were noted, and serum prolactin concentrations showed no change in a subsample of nine patients. Two major side effects appeared to be drug-related: One seizure occurred at 600 mg/day, and elevations of alkaline phosphatase were noted at several doses in six patients.

Duke Scholars

Author Jonathan R.T. Davidson Psychiatry & Behavioral Sciences, Adult Psychiatry & Psychol ...

Author Anthony Thomas Dren School of Nursing

Published In

Drug Development Research

Publication Date

1985

Volume

Issue

Start / End Page

13 / 17

Related Subject Headings

Pharmacology & Pharmacy
3214 Pharmacology and pharmaceutical sciences
1115 Pharmacology and Pharmaceutical Sciences

Citation

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ICMJE

MLA

NLM

Davidson, J., Dren, A., Miller, R., Manberg, P., Kilts, C., & Wingfield, M. (1985). BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects? Drug Development Research, 6(1), 13–17.

Davidson, J., A. Dren, R. Miller, P. Manberg, C. Kilts, and M. Wingfield. “BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects?” Drug Development Research 6, no. 1 (1985): 13–17.

Davidson J, Dren A, Miller R, Manberg P, Kilts C, Wingfield M. BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects? Drug Development Research. 1985;6(1):13–7.

Davidson, J., et al. “BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects?” Drug Development Research, vol. 6, no. 1, 1985, pp. 13–17.

Davidson J, Dren A, Miller R, Manberg P, Kilts C, Wingfield M. BW234U: a non-dopamine receptor blocking antipsychotic drug without extrapyramidal effects? Drug Development Research. 1985;6(1):13–17.