Skip to main content
Journal cover image

Tumor size and endophytic growth pattern affect recurrence rates after laparoscopic renal cryoablation.

Publication ,  Journal Article
Tsivian, M; Lyne, JC; Mayes, JM; Mouraviev, V; Kimura, M; Polascik, TJ
Published in: Urology
February 2010

OBJECTIVE: To analyze factors that may contribute to local relapse after laparoscopic cryoablation (LCA) of renal tumors. LCA has gained popularity in the treatment of small renal tumors, but local tumor control remains a concern. METHODS: We analyzed 163 patients who underwent LCA between 2001 and 2008 either at Allegheny General Hospital or Duke University Medical Center, with at least 6 months of follow-up. Demographics, perioperative variables, tumor characteristics (size, pattern of growth, and biopsy results), and follow-up were recorded. Growth pattern was categorized as exophytic, mesophytic, or endophytic. Regression analyses were performed to evaluate risk factors for local relapse after LCA. RESULTS: Median patient age was 66 (range, 33-90) years, with men comprising 60.1% of the cohort. Median tumor size was 2.4 cm (range, 0.5-5.0). Pathology was as follows: renal cell carcinoma in 118 (72.4%), other malignancies in 2 (1.2%), and no malignancy in 43 (26.4%) patients. A single lesion was treated in 95.1% patients and multiple tumors in 4.9%. Endophytic growth pattern was present in 22.8% patients. We observed 7 (4.3%) local recurrences over a median follow-up of 20 months (range, 6-79). Median time to recurrence was 15 months (range, 6-48). On proportional hazards regression, tumor size and endophytic growth pattern were significantly associated with local recurrence (P = .003 and .028; odds ratios [OR] = 4.1 and 11.4, respectively). CONCLUSIONS: LCA demonstrated good tumor control over a 5-year follow-up, with an acceptable recurrence rate. Larger tumors and those with endophytic growth pattern may be at increased risk of relapse after LCA.

Duke Scholars

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

February 2010

Volume

75

Issue

2

Start / End Page

307 / 310

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Retrospective Studies
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Laparoscopy
  • Kidney Neoplasms
  • Humans
  • Female
  • Cryosurgery
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Tsivian, M., Lyne, J. C., Mayes, J. M., Mouraviev, V., Kimura, M., & Polascik, T. J. (2010). Tumor size and endophytic growth pattern affect recurrence rates after laparoscopic renal cryoablation. Urology, 75(2), 307–310. https://doi.org/10.1016/j.urology.2009.09.039
Tsivian, Matvey, John C. Lyne, Janice M. Mayes, Vladimir Mouraviev, Masaki Kimura, and Thomas J. Polascik. “Tumor size and endophytic growth pattern affect recurrence rates after laparoscopic renal cryoablation.Urology 75, no. 2 (February 2010): 307–10. https://doi.org/10.1016/j.urology.2009.09.039.
Tsivian M, Lyne JC, Mayes JM, Mouraviev V, Kimura M, Polascik TJ. Tumor size and endophytic growth pattern affect recurrence rates after laparoscopic renal cryoablation. Urology. 2010 Feb;75(2):307–10.
Tsivian, Matvey, et al. “Tumor size and endophytic growth pattern affect recurrence rates after laparoscopic renal cryoablation.Urology, vol. 75, no. 2, Feb. 2010, pp. 307–10. Pubmed, doi:10.1016/j.urology.2009.09.039.
Tsivian M, Lyne JC, Mayes JM, Mouraviev V, Kimura M, Polascik TJ. Tumor size and endophytic growth pattern affect recurrence rates after laparoscopic renal cryoablation. Urology. 2010 Feb;75(2):307–310.
Journal cover image

Published In

Urology

DOI

EISSN

1527-9995

Publication Date

February 2010

Volume

75

Issue

2

Start / End Page

307 / 310

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Retrospective Studies
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
  • Laparoscopy
  • Kidney Neoplasms
  • Humans
  • Female
  • Cryosurgery