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Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection.

Publication ,  Journal Article
Chen, VH; Mouraviev, V; Mayes, JM; Sun, L; Madden, JF; Moul, JW; Polascik, TJ
Published in: Technol Cancer Res Treat
April 2009

The 3-D transrectal ultrasound (TRUS)-guided prostate biopsy system is a novel device that allows precise needle placement in a template fashion. We evaluate its utility for prostate cancer (PCa) detection. A retrospective analysis was performed evaluating 68 prospective patients at the Duke Prostate Center who underwent a prostate biopsy using a 3-D TRUS-guided system. After creation of a three-dimensional map of the prostate, a computer algorithm identified an ideal biopsy scheme based on the measured dimensions of the prostate. The system then used a fixed template that allowed prostate biopsy at specific locations with the ability to target the same region of the prostate in the future if needed. For all patients, a 12-core biopsy pattern was used to cover medial and lateral areas of the base, mid-gland, and apex. In total, 68 patients underwent 3-D TRUS-guided prostate biopsies between April 2006 and November 2007 for prostate cancer detection. The indication for prostate biopsy was PSA > or = 4.0 ng/ml in 47 (69%) patients, abnormal digital rectal examination (DRE) in 17 (25%), and atypia on previous biopsy in 4 (6%) patients. Prostate cancer was detected in 18 patients (26.5%) and 7 (10.3%) had atypical small acinar proliferation (ASAP). The highest frequency (55.5%) from all cases of cancer detected was identified when 3-D TRUS biopsy was used as the initial biopsy. This study demonstrates that a 3-D TRUS-guided biopsy system translates to a more frequent detection of prostate cancer among patients undergoing an initial prostate biopsy than a subsequent one. More comprehensive studies are warranted to corroborate and extend the results of this study.

Duke Scholars

Published In

Technol Cancer Res Treat

DOI

ISSN

1533-0346

Publication Date

April 2009

Volume

8

Issue

2

Start / End Page

99 / 104

Location

United States

Related Subject Headings

  • Ultrasound, High-Intensity Focused, Transrectal
  • Ultrasonography
  • Retrospective Studies
  • Prostatic Neoplasms
  • Prostatectomy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional
  • Humans
 

Citation

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Chen, V. H., Mouraviev, V., Mayes, J. M., Sun, L., Madden, J. F., Moul, J. W., & Polascik, T. J. (2009). Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection. Technol Cancer Res Treat, 8(2), 99–104. https://doi.org/10.1177/153303460900800202
Chen, Valerie H., Vladimir Mouraviev, Janice M. Mayes, Leon Sun, John F. Madden, Judd W. Moul, and Thomas J. Polascik. “Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection.Technol Cancer Res Treat 8, no. 2 (April 2009): 99–104. https://doi.org/10.1177/153303460900800202.
Chen VH, Mouraviev V, Mayes JM, Sun L, Madden JF, Moul JW, et al. Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection. Technol Cancer Res Treat. 2009 Apr;8(2):99–104.
Chen, Valerie H., et al. “Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection.Technol Cancer Res Treat, vol. 8, no. 2, Apr. 2009, pp. 99–104. Pubmed, doi:10.1177/153303460900800202.
Chen VH, Mouraviev V, Mayes JM, Sun L, Madden JF, Moul JW, Polascik TJ. Utility of a 3-dimensional transrectal ultrasound-guided prostate biopsy system for prostate cancer detection. Technol Cancer Res Treat. 2009 Apr;8(2):99–104.
Journal cover image

Published In

Technol Cancer Res Treat

DOI

ISSN

1533-0346

Publication Date

April 2009

Volume

8

Issue

2

Start / End Page

99 / 104

Location

United States

Related Subject Headings

  • Ultrasound, High-Intensity Focused, Transrectal
  • Ultrasonography
  • Retrospective Studies
  • Prostatic Neoplasms
  • Prostatectomy
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Imaging, Three-Dimensional
  • Humans