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The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) Trial.

Publication ,  Journal Article
Jacobs, DR; Gross, MD; Steffen, L; Steffes, MW; Yu, X; Svetkey, LP; Appel, LJ; Vollmer, WM; Bray, GA; Moore, T; Conlin, PR; Sacks, F
Published in: Am J Kidney Dis
April 2009

BACKGROUND: Dietary studies designed to decrease the urinary albumin excretion rate (AER) typically reduce protein by increasing lower protein plant foods and decreasing higher protein animal products. STUDY DESIGN: We evaluated AER while increasing protein intake in the Dietary Approaches to Stop Hypertension (DASH) Trial (randomized, parallel group, 8 week controlled feeding). SETTING & PARTICIPANTS: 378 individuals without diabetes with prehypertension or stage I hypertension. INTERVENTION: The DASH diet, 18% energy from protein, emphasizes, among other features, low-fat dairy products; and the fruit/vegetable (FV) and control diets, each with 15% energy from protein. OUTCOME: AER. MEASUREMENTS: We measured AER by using immunoassay and covariates at baseline and after 8 weeks. RESULTS: Baseline AER had a geometric mean value of 4.0 +/- 0.2 (SE) mg/24 h. In 285 participants with baseline AER less than 7 mg/24 h, AER was unchanged by diet treatment (geometric mean, 2.5 +/- 0.2 mg/24 h in the control diet, 3.0 +/- 0.2 mg/24 h in the FV diet, and 2.8 +/- 0.2 mg/24 h in the DASH diet). Conversely, in 93 participants with baseline AER of 7 mg/24 h or greater, end-of-feeding AER was lower in the FV diet (6.6 +/- 1.0 mg/24 h) than in the control (11.4 +/- 1.8 mg/24 h; P = 0.01) or DASH diets (11.7 +/- 1.6 mg/24 h; P = 0.005). The DASH and control diets were not different (P = 0.9). LIMITATIONS: Long-term AER change not studied. CONCLUSIONS: The decrease in AER after 8 weeks occurred in only those with high-normal baseline AER in the FV diet, in a pattern distinct from the blood pressure decrease. The DASH diet did not increase AER despite a 3% increase in energy from protein.

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Published In

Am J Kidney Dis

DOI

EISSN

1523-6838

Publication Date

April 2009

Volume

53

Issue

4

Start / End Page

638 / 646

Location

United States

Related Subject Headings

  • Vegetables
  • Urology & Nephrology
  • Treatment Outcome
  • Risk Factors
  • Middle Aged
  • Male
  • Kidney Diseases
  • Hypertension
  • Humans
  • Fruit
 

Citation

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Jacobs, D. R., Gross, M. D., Steffen, L., Steffes, M. W., Yu, X., Svetkey, L. P., … Sacks, F. (2009). The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Kidney Dis, 53(4), 638–646. https://doi.org/10.1053/j.ajkd.2008.10.048
Jacobs, David R., Myron D. Gross, Lyn Steffen, Michael W. Steffes, Xinhua Yu, Laura P. Svetkey, Lawrence J. Appel, et al. “The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) Trial.Am J Kidney Dis 53, no. 4 (April 2009): 638–46. https://doi.org/10.1053/j.ajkd.2008.10.048.
Jacobs DR, Gross MD, Steffen L, Steffes MW, Yu X, Svetkey LP, et al. The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Kidney Dis. 2009 Apr;53(4):638–46.
Jacobs, David R., et al. “The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) Trial.Am J Kidney Dis, vol. 53, no. 4, Apr. 2009, pp. 638–46. Pubmed, doi:10.1053/j.ajkd.2008.10.048.
Jacobs DR, Gross MD, Steffen L, Steffes MW, Yu X, Svetkey LP, Appel LJ, Vollmer WM, Bray GA, Moore T, Conlin PR, Sacks F. The effects of dietary patterns on urinary albumin excretion: results of the Dietary Approaches to Stop Hypertension (DASH) Trial. Am J Kidney Dis. 2009 Apr;53(4):638–646.
Journal cover image

Published In

Am J Kidney Dis

DOI

EISSN

1523-6838

Publication Date

April 2009

Volume

53

Issue

4

Start / End Page

638 / 646

Location

United States

Related Subject Headings

  • Vegetables
  • Urology & Nephrology
  • Treatment Outcome
  • Risk Factors
  • Middle Aged
  • Male
  • Kidney Diseases
  • Hypertension
  • Humans
  • Fruit