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Physiological correlates of HIV-related fatigue.

Publication ,  Journal Article
Barroso, J; Pence, BW; Salahuddin, N; Harmon, JL; Leserman, J
Published in: Clin Nurs Res
February 2008

Our primary aim is to describe the relationship of multiple physiological variables and HIV-related fatigue. We report baseline data collected from 128 human immunodeficiency virus (HIV)-positive individuals. The HIV-Related Fatigue Scale was used to measure several aspects of fatigue. Blood was drawn for the following physiological variables: hepatic function, thyroid function, HIV viral load, immunologic function, gonadal function, hematologic function, serum cortisol, and cellular injury. In bivariable analyses, free testosterone (p=0.03) and CD8 (p=0.07) were negatively correlated with fatigue intensity, and nonlinear relationships were observed between fatigue intensity and total testosterone (p=0.02), thyroxine (p=0.01), hematocrit (p=0.06), and total bilirubin (p=0.06). However, none of these associations persisted in multivariable models. It is possible that fatigue suffered by seropositive people is better predicted by other variables, which must be better understood to develop interventions to successfully ameliorate HIV-related fatigue.

Duke Scholars

Published In

Clin Nurs Res

DOI

ISSN

1054-7738

Publication Date

February 2008

Volume

17

Issue

1

Start / End Page

5 / 19

Location

United States

Related Subject Headings

  • Viral Load
  • Thyroxine
  • Testosterone
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Risk Factors
  • Predictive Value of Tests
  • Nursing Research
  • Nursing
  • Nonlinear Dynamics
 

Citation

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Barroso, J., Pence, B. W., Salahuddin, N., Harmon, J. L., & Leserman, J. (2008). Physiological correlates of HIV-related fatigue. Clin Nurs Res, 17(1), 5–19. https://doi.org/10.1177/1054773807311382
Barroso, Julie, Brian Wells Pence, Naima Salahuddin, James L. Harmon, and Jane Leserman. “Physiological correlates of HIV-related fatigue.Clin Nurs Res 17, no. 1 (February 2008): 5–19. https://doi.org/10.1177/1054773807311382.
Barroso J, Pence BW, Salahuddin N, Harmon JL, Leserman J. Physiological correlates of HIV-related fatigue. Clin Nurs Res. 2008 Feb;17(1):5–19.
Barroso, Julie, et al. “Physiological correlates of HIV-related fatigue.Clin Nurs Res, vol. 17, no. 1, Feb. 2008, pp. 5–19. Pubmed, doi:10.1177/1054773807311382.
Barroso J, Pence BW, Salahuddin N, Harmon JL, Leserman J. Physiological correlates of HIV-related fatigue. Clin Nurs Res. 2008 Feb;17(1):5–19.
Journal cover image

Published In

Clin Nurs Res

DOI

ISSN

1054-7738

Publication Date

February 2008

Volume

17

Issue

1

Start / End Page

5 / 19

Location

United States

Related Subject Headings

  • Viral Load
  • Thyroxine
  • Testosterone
  • Surveys and Questionnaires
  • Severity of Illness Index
  • Risk Factors
  • Predictive Value of Tests
  • Nursing Research
  • Nursing
  • Nonlinear Dynamics