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5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.

Publication ,  Journal Article
Brummett, BH; Muller, CL; Collins, AL; Boyle, SH; Kuhn, CM; Siegler, IC; Williams, RB; Ashley-Koch, A
Published in: Behav Genet
September 2008

Expression of the serotonin transporter is affected by the genotype of the 5-HTTLPR (short and long forms) as well as the genotype of the SNP rs25531 within this region. Based on the combined genotypes for these polymorphisms, we designated each allele as a high or low expressing allele according to established expression levels-resulting in HiHi, HiLo, & LoLo genotype groups for analysis. We evaluated effects of gender and the promoter genotype on induction of negative affect by intravenous infusion of L: -tryptophan (TRP). The protocol consisted of a day-1 sham saline infusion and a day-2 active TRP infusion. Models assessed 5-HTTLPR composite genotype and gender as predictors of change in ratings of negative emotion during TRP infusion. During sham infusion there were no significant changes from baseline in mood ratings. During TRP infusion all negative affect ratings increased significantly from baseline (P's < .02). The genotype x gender interaction was a significant predictor of depression-dejection (P = .013), and trended towards predicting anger-hostility (P = .084). Males in the HiHi group had greater increases in negative affect during infusion, compared to all groups except LoLo females, who also showed increased negative affect.

Duke Scholars

Published In

Behav Genet

DOI

EISSN

1573-3297

Publication Date

September 2008

Volume

38

Issue

5

Start / End Page

476 / 483

Location

United States

Related Subject Headings

  • Tryptophan
  • Sex Factors
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Male
  • Humans
  • Hostility
  • Genotype
 

Citation

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MLA
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Brummett, B. H., Muller, C. L., Collins, A. L., Boyle, S. H., Kuhn, C. M., Siegler, I. C., … Ashley-Koch, A. (2008). 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet, 38(5), 476–483. https://doi.org/10.1007/s10519-008-9219-y
Brummett, Beverly H., Christopher L. Muller, Ann L. Collins, Stephen H. Boyle, Cynthia M. Kuhn, Ilene C. Siegler, Redford B. Williams, and Allison Ashley-Koch. “5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.Behav Genet 38, no. 5 (September 2008): 476–83. https://doi.org/10.1007/s10519-008-9219-y.
Brummett BH, Muller CL, Collins AL, Boyle SH, Kuhn CM, Siegler IC, et al. 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet. 2008 Sep;38(5):476–83.
Brummett, Beverly H., et al. “5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion.Behav Genet, vol. 38, no. 5, Sept. 2008, pp. 476–83. Pubmed, doi:10.1007/s10519-008-9219-y.
Brummett BH, Muller CL, Collins AL, Boyle SH, Kuhn CM, Siegler IC, Williams RB, Ashley-Koch A. 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet. 2008 Sep;38(5):476–483.
Journal cover image

Published In

Behav Genet

DOI

EISSN

1573-3297

Publication Date

September 2008

Volume

38

Issue

5

Start / End Page

476 / 483

Location

United States

Related Subject Headings

  • Tryptophan
  • Sex Factors
  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin
  • Polymorphism, Single Nucleotide
  • Polymorphism, Genetic
  • Male
  • Humans
  • Hostility
  • Genotype