Skip to main content

Mortality before or during treatment among tuberculosis patients in North Carolina, 1993-2003.

Publication ,  Journal Article
Nguyen, LT; Hamilton, CD; Xia, Q; Stout, JE
Published in: Int J Tuberc Lung Dis
February 2011

SETTING: North Carolina, United States. OBJECTIVE: To investigate the demographic and behavioral risk factors associated with death among tuberculosis (TB) patients in North Carolina. DESIGN: Retrospective cohort of all TB patients reported in North Carolina, 1993-2003 (inclusive). A surveillance dataset based upon Report of Verified Case of Tuberculosis (RVCT) records was cross-linked with the National Death Index (NDI) to confirm date of death and capture additional deaths. RESULTS: Among 5311 TB patients, 181 died before initiation of TB treatment, and 540 died before completion of TB treatment. Increasing age, miliary/meningeal disease, and human immunodeficiency virus (HIV) infection were associated with increased risk of death before treatment, during early treatment (initial 8 weeks) and later in TB treatment. In addition to these factors, excess alcohol use (HR 1.62, 95%CI 1.13-2.32) and residence in a nursing home (HR 1.65, 95%CI 1.20-2.29) were associated with a significantly increased risk of death during the first 8 weeks of treatment. CONCLUSION: Many of the deaths in TB patients occurred in the most vulnerable populations, such as the elderly or those with HIV infection, and may be attributable to delayed diagnosis and poor functional status.

Duke Scholars

Published In

Int J Tuberc Lung Dis

EISSN

1815-7920

Publication Date

February 2011

Volume

15

Issue

2

Start / End Page

257 / i

Location

France

Related Subject Headings

  • Young Adult
  • Tuberculosis, Pulmonary
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Registries
  • Proportional Hazards Models
  • Odds Ratio
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nguyen, L. T., Hamilton, C. D., Xia, Q., & Stout, J. E. (2011). Mortality before or during treatment among tuberculosis patients in North Carolina, 1993-2003. Int J Tuberc Lung Dis, 15(2), 257–i.
Nguyen, L. T., C. D. Hamilton, Q. Xia, and J. E. Stout. “Mortality before or during treatment among tuberculosis patients in North Carolina, 1993-2003.Int J Tuberc Lung Dis 15, no. 2 (February 2011): 257–i.
Nguyen LT, Hamilton CD, Xia Q, Stout JE. Mortality before or during treatment among tuberculosis patients in North Carolina, 1993-2003. Int J Tuberc Lung Dis. 2011 Feb;15(2):257–i.
Nguyen, L. T., et al. “Mortality before or during treatment among tuberculosis patients in North Carolina, 1993-2003.Int J Tuberc Lung Dis, vol. 15, no. 2, Feb. 2011, pp. 257–i.
Nguyen LT, Hamilton CD, Xia Q, Stout JE. Mortality before or during treatment among tuberculosis patients in North Carolina, 1993-2003. Int J Tuberc Lung Dis. 2011 Feb;15(2):257–i.

Published In

Int J Tuberc Lung Dis

EISSN

1815-7920

Publication Date

February 2011

Volume

15

Issue

2

Start / End Page

257 / i

Location

France

Related Subject Headings

  • Young Adult
  • Tuberculosis, Pulmonary
  • Treatment Outcome
  • Time Factors
  • Risk Factors
  • Risk Assessment
  • Retrospective Studies
  • Registries
  • Proportional Hazards Models
  • Odds Ratio