Skip to main content
Journal cover image

Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis.

Publication ,  Journal Article
Reddy, SK; Pawlik, TM; Zorzi, D; Gleisner, AL; Ribero, D; Assumpcao, L; Barbas, AS; Abdalla, EK; Choti, MA; Vauthey, J-N; Ludwig, KA ...
Published in: Ann Surg Oncol
December 2007

BACKGROUND: The safety of simultaneous resections of colorectal cancer and synchronous liver metastases (SCRLM) is not established. This multi-institutional retrospective study compared postoperative outcomes after simultaneous and staged colorectal and hepatic resections. METHODS: Clinicopathologic data, treatments, and postoperative outcomes from patients who underwent simultaneous or staged colorectal and hepatic resections at three hepatobiliary centers from 1985-2006 were reviewed. RESULTS: 610 patients underwent simultaneous (n = 135) or staged (n = 475) resections of colorectal cancer and SCRLM. Seventy staged patients underwent colorectal and hepatic resections at the same institution. Simultaneous patients had fewer (median 1 versus 2) and smaller (median 2.5 versus 3.5 cm) metastases and less often underwent major (> or = three segments) hepatectomy (26.7% versus 61.3%, p < 0.05). Combined hospital stay was lower after simultaneous resections (median 8.5 versus 14 days, p < 0.0001). Mortality (1.0% versus 0.5%) and severe morbidity (14.1% versus 12.5%) were similar after simultaneous colorectal resection and minor hepatectomy compared with isolated minor hepatectomy (both p > 0.05). For major hepatectomy, simultaneous colorectal resection increased mortality (8.3% versus 1.4%, p < 0.05) and severe morbidity (36.1% versus 15.1%, p < 0.05). Combined severe morbidity after staged resections was lower compared to simultaneous resections (36.1% versus 17.6%, p = 0.05) for major hepatectomy but similar for minor hepatectomy (14.1% versus 10.5%, p > 0.05). Major hepatectomy independently predicted severe morbidity after simultaneous resections [hazard ratio (HR) = 3.4, p = 0.008]. CONCLUSIONS: Simultaneous colorectal and minor hepatic resections are safe and should be performed for most patients with SCRLM. Due to increased risk of severe morbidity, caution should be exercised before performing simultaneous colorectal and major hepatic resections.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

December 2007

Volume

14

Issue

12

Start / End Page

3481 / 3491

Location

United States

Related Subject Headings

  • Survival Rate
  • Retrospective Studies
  • Prognosis
  • Postoperative Complications
  • Oncology & Carcinogenesis
  • Morbidity
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Reddy, S. K., Pawlik, T. M., Zorzi, D., Gleisner, A. L., Ribero, D., Assumpcao, L., … Clary, B. M. (2007). Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Ann Surg Oncol, 14(12), 3481–3491. https://doi.org/10.1245/s10434-007-9522-5
Reddy, Srinevas K., Timothy M. Pawlik, Daria Zorzi, Ana L. Gleisner, Dario Ribero, Lia Assumpcao, Andrew S. Barbas, et al. “Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis.Ann Surg Oncol 14, no. 12 (December 2007): 3481–91. https://doi.org/10.1245/s10434-007-9522-5.
Reddy SK, Pawlik TM, Zorzi D, Gleisner AL, Ribero D, Assumpcao L, et al. Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Ann Surg Oncol. 2007 Dec;14(12):3481–91.
Reddy, Srinevas K., et al. “Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis.Ann Surg Oncol, vol. 14, no. 12, Dec. 2007, pp. 3481–91. Pubmed, doi:10.1245/s10434-007-9522-5.
Reddy SK, Pawlik TM, Zorzi D, Gleisner AL, Ribero D, Assumpcao L, Barbas AS, Abdalla EK, Choti MA, Vauthey J-N, Ludwig KA, Mantyh CR, Morse MA, Clary BM. Simultaneous resections of colorectal cancer and synchronous liver metastases: a multi-institutional analysis. Ann Surg Oncol. 2007 Dec;14(12):3481–3491.
Journal cover image

Published In

Ann Surg Oncol

DOI

EISSN

1534-4681

Publication Date

December 2007

Volume

14

Issue

12

Start / End Page

3481 / 3491

Location

United States

Related Subject Headings

  • Survival Rate
  • Retrospective Studies
  • Prognosis
  • Postoperative Complications
  • Oncology & Carcinogenesis
  • Morbidity
  • Middle Aged
  • Male
  • Liver Neoplasms
  • Humans