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A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver model.

Publication ,  Journal Article
Baccarani, A; Follmar, KE; Das, RR; Mukundan, S; Marcus, JR; Levin, LS; Erdmann, D
Published in: Plast Reconstr Surg
January 2007

BACKGROUND: Face transplantation may become a viable alternative in the treatment of patients with severe acquired facial deformity. In this study, the authors investigate morphological compatibility between donor and recipient by assessing chimeric outcomes in a human cadaver model. METHODS: Four faces were harvested from fresh human cadaver specimens in a surgical plane deep to the galea, to the superficial musculoaponeurotic system, and to the platysma. The faces were subsequently exchanged among the four donor crania, simulating full-face transplantations. Eight cranium-face chimera complexes were created and analyzed with standardized photography and with volumetric computed tomographic radiography. RESULTS: Four morphological parameters to consider in determining donor/recipient compatibility were defined: (1) skin color and texture, (2) head size, (3) soft-tissue features, and (4) gender. CONCLUSION: Careful selection of face donors based on compatibility criteria will aid in ensuring that the posttransplant outcome is morphologically similar to the recipient's native face.

Duke Scholars

Published In

Plast Reconstr Surg

DOI

EISSN

1529-4242

Publication Date

January 2007

Volume

119

Issue

1

Start / End Page

121 / 129

Location

United States

Related Subject Headings

  • Transplants
  • Transplantation
  • Tissue Donors
  • Surgery
  • Pilot Projects
  • Middle Aged
  • Humans
  • Histocompatibility
  • Female
  • Feasibility Studies
 

Citation

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Baccarani, A., Follmar, K. E., Das, R. R., Mukundan, S., Marcus, J. R., Levin, L. S., & Erdmann, D. (2007). A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver model. Plast Reconstr Surg, 119(1), 121–129. https://doi.org/10.1097/01.prs.0000245078.66513.c0
Baccarani, Alessio, Keith E. Follmar, Rajesh R. Das, Srinivasan Mukundan, Jeffrey R. Marcus, L Scott Levin, and Detlev Erdmann. “A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver model.Plast Reconstr Surg 119, no. 1 (January 2007): 121–29. https://doi.org/10.1097/01.prs.0000245078.66513.c0.
Baccarani A, Follmar KE, Das RR, Mukundan S, Marcus JR, Levin LS, et al. A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver model. Plast Reconstr Surg. 2007 Jan;119(1):121–9.
Baccarani, Alessio, et al. “A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver model.Plast Reconstr Surg, vol. 119, no. 1, Jan. 2007, pp. 121–29. Pubmed, doi:10.1097/01.prs.0000245078.66513.c0.
Baccarani A, Follmar KE, Das RR, Mukundan S, Marcus JR, Levin LS, Erdmann D. A pilot study in sub-SMAS face transplantation: defining donor compatibility and assessing outcomes in a cadaver model. Plast Reconstr Surg. 2007 Jan;119(1):121–129.

Published In

Plast Reconstr Surg

DOI

EISSN

1529-4242

Publication Date

January 2007

Volume

119

Issue

1

Start / End Page

121 / 129

Location

United States

Related Subject Headings

  • Transplants
  • Transplantation
  • Tissue Donors
  • Surgery
  • Pilot Projects
  • Middle Aged
  • Humans
  • Histocompatibility
  • Female
  • Feasibility Studies