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Heptahelical terpsichory. Who calls the tune?

Publication ,  Journal Article
Gesty-Palmer, D; Luttrell, LM
Published in: J Recept Signal Transduct Res
2008

The discovery that arrestins can function as ligand-regulated signaling scaffolds has revealed a previously unappreciated level of complexity in G protein-coupled receptor (GPCR) signal transduction. Because arrestin-bound GPCRs are uncoupled from G proteins, arrestin binding can be viewed as switching receptors between two temporally and spatially distinct signaling modes. Recent work has established two factors that underscore this duality of GPCR signaling and suggest it may ultimately have therapeutic significance. The first is that signaling by receptor-arrestin "signalsomes" does not require heterotrimeric G protein activation. The second is that arrestin-dependent signals can be initiated by pathway-specific "biased agonists," creating the potential for drugs that selectively modulate different aspects of GPCR function. Currently, however, little is known about the physiological relevance of G protein-independent signals at the cellular or whole animal levels, and additional work is needed to determine whether arrestin pathway-selective drugs will find clinical application.

Duke Scholars

Published In

J Recept Signal Transduct Res

DOI

ISSN

1079-9893

Publication Date

2008

Volume

28

Issue

1-2

Start / End Page

39 / 58

Location

England

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Mutation
  • Models, Biological
  • Ligands
  • Humans
  • Heterotrimeric GTP-Binding Proteins
  • Biochemistry & Molecular Biology
  • Arrestins
 

Citation

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Gesty-Palmer, D., & Luttrell, L. M. (2008). Heptahelical terpsichory. Who calls the tune? J Recept Signal Transduct Res, 28(1–2), 39–58. https://doi.org/10.1080/10799890801941921
Gesty-Palmer, Diane, and Louis M. Luttrell. “Heptahelical terpsichory. Who calls the tune?J Recept Signal Transduct Res 28, no. 1–2 (2008): 39–58. https://doi.org/10.1080/10799890801941921.
Gesty-Palmer D, Luttrell LM. Heptahelical terpsichory. Who calls the tune? J Recept Signal Transduct Res. 2008;28(1–2):39–58.
Gesty-Palmer, Diane, and Louis M. Luttrell. “Heptahelical terpsichory. Who calls the tune?J Recept Signal Transduct Res, vol. 28, no. 1–2, 2008, pp. 39–58. Pubmed, doi:10.1080/10799890801941921.
Gesty-Palmer D, Luttrell LM. Heptahelical terpsichory. Who calls the tune? J Recept Signal Transduct Res. 2008;28(1–2):39–58.
Journal cover image

Published In

J Recept Signal Transduct Res

DOI

ISSN

1079-9893

Publication Date

2008

Volume

28

Issue

1-2

Start / End Page

39 / 58

Location

England

Related Subject Headings

  • beta-Arrestins
  • Signal Transduction
  • Receptors, G-Protein-Coupled
  • Mutation
  • Models, Biological
  • Ligands
  • Humans
  • Heterotrimeric GTP-Binding Proteins
  • Biochemistry & Molecular Biology
  • Arrestins