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Antiplatelet therapy in older adults with non-ST-segment elevation acute coronary syndrome: considering risks and benefits.

Publication ,  Journal Article
Lopes, RD; Alexander, KP
Published in: Am J Cardiol
September 7, 2009

Antiplatelet agents play an important role in the treatment of non-ST-segment elevation acute coronary syndromes (NSTE ACS), particularly for those at high risk, such as older adults (aged > or =75 years) where treatment may yield the greatest benefits. Paradoxically, older adults are also at higher risk from bleeding complications. Most randomized trials have enrolled few older persons, so data are sparse with which to guide clinical practice. In this review, we highlight the relevant trial evidence for antiplatelet therapy (aspirin, P2Y(12) inhibitors, and small molecule glycoprotein IIb/IIIa inhibitors) in NSTE ACS in relation to age, taking into consideration the risks and benefits, dose, concomitant therapy, and duration of use. Given greater potential benefits from primary and secondary prevention strategies in cardiovascular care, it is important to apply guideline recommendations in older adults. However, given their complexity, it is important to further consider the application of existing and new therapies and strategies of care in "real-world" settings.

Duke Scholars

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

September 7, 2009

Volume

104

Issue

5 Suppl

Start / End Page

16C / 21C

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Platelet Aggregation Inhibitors
  • Middle Aged
  • Humans
  • Cardiovascular System & Hematology
  • Aged, 80 and over
  • Aged
  • Age Factors
  • Acute Coronary Syndrome
 

Citation

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Lopes, R. D., & Alexander, K. P. (2009). Antiplatelet therapy in older adults with non-ST-segment elevation acute coronary syndrome: considering risks and benefits. Am J Cardiol, 104(5 Suppl), 16C-21C. https://doi.org/10.1016/j.amjcard.2009.06.021
Lopes, Renato D., and Karen P. Alexander. “Antiplatelet therapy in older adults with non-ST-segment elevation acute coronary syndrome: considering risks and benefits.Am J Cardiol 104, no. 5 Suppl (September 7, 2009): 16C-21C. https://doi.org/10.1016/j.amjcard.2009.06.021.
Lopes, Renato D., and Karen P. Alexander. “Antiplatelet therapy in older adults with non-ST-segment elevation acute coronary syndrome: considering risks and benefits.Am J Cardiol, vol. 104, no. 5 Suppl, Sept. 2009, pp. 16C-21C. Pubmed, doi:10.1016/j.amjcard.2009.06.021.
Journal cover image

Published In

Am J Cardiol

DOI

EISSN

1879-1913

Publication Date

September 7, 2009

Volume

104

Issue

5 Suppl

Start / End Page

16C / 21C

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk Assessment
  • Platelet Aggregation Inhibitors
  • Middle Aged
  • Humans
  • Cardiovascular System & Hematology
  • Aged, 80 and over
  • Aged
  • Age Factors
  • Acute Coronary Syndrome