Skip to main content
Journal cover image

Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).

Publication ,  Journal Article
Dhar, R; Alsheikh-Ali, AA; Estes, NAM; Moss, AJ; Zareba, W; Daubert, JP; Greenberg, H; Case, RB; Kent, DM
Published in: Heart Rhythm
June 2008

BACKGROUND: There is conflicting literature on the relationship between prolonged QRS duration (QRSd) and arrhythmic events, including sudden cardiac death (SCD), in heart failure patients with or without implantable cardioverter-defibrillators (ICDs). OBJECTIVE: The purpose of this study was to evaluate the prognostic significance of prolonged QRSd relative to arrhythmic outcomes in medically and ICD-treated patients enrolled in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II. METHODS: Using a Cox proportional hazards model adjusting for ejection fraction, heart failure class, and blood urea nitrogen, we estimated the association of prolonged QRSd >/=140 ms with SCD in the medically treated arm and SCD or first appropriate ICD therapy for rapid ventricular tachycardia/fibrillation (VT/VF; cycle length

Duke Scholars

Published In

Heart Rhythm

DOI

EISSN

1556-3871

Publication Date

June 2008

Volume

5

Issue

6

Start / End Page

807 / 813

Location

United States

Related Subject Headings

  • Time Factors
  • Tachycardia, Ventricular
  • Stroke Volume
  • Severity of Illness Index
  • Risk Factors
  • Proportional Hazards Models
  • Prognosis
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dhar, R., Alsheikh-Ali, A. A., Estes, N. A. M., Moss, A. J., Zareba, W., Daubert, J. P., … Kent, D. M. (2008). Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II). Heart Rhythm, 5(6), 807–813. https://doi.org/10.1016/j.hrthm.2008.02.013
Dhar, Ritesh, Alawi A. Alsheikh-Ali, NA Mark Estes, Arthur J. Moss, Wojciech Zareba, James P. Daubert, Henry Greenberg, Robert B. Case, and David M. Kent. “Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).Heart Rhythm 5, no. 6 (June 2008): 807–13. https://doi.org/10.1016/j.hrthm.2008.02.013.
Dhar, Ritesh, et al. “Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II).Heart Rhythm, vol. 5, no. 6, June 2008, pp. 807–13. Pubmed, doi:10.1016/j.hrthm.2008.02.013.
Dhar R, Alsheikh-Ali AA, Estes NAM, Moss AJ, Zareba W, Daubert JP, Greenberg H, Case RB, Kent DM. Association of prolonged QRS duration with ventricular tachyarrhythmias and sudden cardiac death in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II). Heart Rhythm. 2008 Jun;5(6):807–813.
Journal cover image

Published In

Heart Rhythm

DOI

EISSN

1556-3871

Publication Date

June 2008

Volume

5

Issue

6

Start / End Page

807 / 813

Location

United States

Related Subject Headings

  • Time Factors
  • Tachycardia, Ventricular
  • Stroke Volume
  • Severity of Illness Index
  • Risk Factors
  • Proportional Hazards Models
  • Prognosis
  • Middle Aged
  • Male
  • Humans