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Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator.

Publication ,  Journal Article
Moss, AJ; Greenberg, H; Case, RB; Zareba, W; Hall, WJ; Brown, MW; Daubert, JP; McNitt, S; Andrews, ML; Elkin, AD ...
Published in: Circulation
December 21, 2004

BACKGROUND: The implanted cardioverter defibrillator (ICD) improves survival in high-risk cardiac patients. This analysis from the MADIT-II trial database examines the long-term clinical course and subsequent mortality risk of patients after termination of life-threatening ventricular tachyarrhythmias by an ICD. METHODS AND RESULTS: Life-table survival analysis was performed, and proportional hazards regression analysis was used to evaluate the contribution of baseline clinical factors and time-dependent defibrillator therapy to mortality during long-term follow-up. Of 720 patients with an ICD (average follow-up 21 months), 169 patients received 701 antiarrhythmic device therapies for ventricular tachyarrhythmias. Few baseline characteristics distinguished patients who received appropriate ICD therapy for their first ventricular tachyarrhythmic episode. The probability of survival for at least 1 year after first therapy for ventricular tachycardia (VT) or ventricular fibrillation (VF) was 80%. The hazard ratios for the risk of death due to any cause in those who survived appropriate therapy for termination of VT and VF were 3.4 (P<0.001) and 3.3 (P=0.01), respectively, compared with those who survived without receiving ICD therapy, with a high frequency of heart failure and late nonsudden cardiac death after first successful ICD therapy for VF. CONCLUSIONS: Successful appropriate therapy by an ICD for VT or VF is associated with 80% survival at 1 year after arrhythmia termination. These patients are at increased risk for heart failure and nonsudden cardiac death after device termination of VT or VF and should receive special attention for the prevention and management of progressive left ventricular dysfunction during long-term follow-up.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

December 21, 2004

Volume

110

Issue

25

Start / End Page

3760 / 3765

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Tachycardia, Ventricular
  • Survival Analysis
  • Risk
  • Randomized Controlled Trials as Topic
  • Proportional Hazards Models
  • Prognosis
  • Life Tables
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Moss, A. J., Greenberg, H., Case, R. B., Zareba, W., Hall, W. J., Brown, M. W., … Multicenter Automatic Defibrillator Implantation Trial-II (MADIT-II) Research Group, . (2004). Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator. Circulation, 110(25), 3760–3765. https://doi.org/10.1161/01.CIR.0000150390.04704.B7
Moss, Arthur J., Henry Greenberg, Robert B. Case, Wojciech Zareba, W Jackson Hall, Mary W. Brown, James P. Daubert, et al. “Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator.Circulation 110, no. 25 (December 21, 2004): 3760–65. https://doi.org/10.1161/01.CIR.0000150390.04704.B7.
Moss AJ, Greenberg H, Case RB, Zareba W, Hall WJ, Brown MW, et al. Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator. Circulation. 2004 Dec 21;110(25):3760–5.
Moss, Arthur J., et al. “Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator.Circulation, vol. 110, no. 25, Dec. 2004, pp. 3760–65. Pubmed, doi:10.1161/01.CIR.0000150390.04704.B7.
Moss AJ, Greenberg H, Case RB, Zareba W, Hall WJ, Brown MW, Daubert JP, McNitt S, Andrews ML, Elkin AD, Multicenter Automatic Defibrillator Implantation Trial-II (MADIT-II) Research Group. Long-term clinical course of patients after termination of ventricular tachyarrhythmia by an implanted defibrillator. Circulation. 2004 Dec 21;110(25):3760–3765.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

December 21, 2004

Volume

110

Issue

25

Start / End Page

3760 / 3765

Location

United States

Related Subject Headings

  • Ventricular Dysfunction, Left
  • Treatment Outcome
  • Tachycardia, Ventricular
  • Survival Analysis
  • Risk
  • Randomized Controlled Trials as Topic
  • Proportional Hazards Models
  • Prognosis
  • Life Tables
  • Humans