Moxifloxacin-induced torsades de pointes.
Publication
, Journal Article
Sherazi, S; DiSalle, M; Daubert, JP; Shah, AH
Published in: Cardiol J
2008
Torsade de pointes (TdP) is increasingly recognized as a complication of drug therapy. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed potassium current (I(Kr)). Moxifloxacin, a widely used fluoroquinolone, is a weak I(Kr) inhibitor and has been associated with QT prolongation. We report a case of marked QT prolongation (618 ms) and TdP associated with moxifloxacin use. Although it is difficult to predict which patients are at risk from TdP, careful assessment of the risk/benefit ratio is important before prescribing drugs known to cause QT prolongation.
Duke Scholars
Published In
Cardiol J
EISSN
1898-018X
Publication Date
2008
Volume
15
Issue
1
Start / End Page
71 / 73
Location
Poland
Related Subject Headings
- Torsades de Pointes
- Quinolines
- Moxifloxacin
- Male
- Humans
- Fluoroquinolones
- Electrocardiography
- Cardiovascular System & Hematology
- Aza Compounds
- Anti-Infective Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Sherazi, S., DiSalle, M., Daubert, J. P., & Shah, A. H. (2008). Moxifloxacin-induced torsades de pointes. Cardiol J, 15(1), 71–73.
Sherazi, Saadia, Michael DiSalle, James P. Daubert, and Abrar H. Shah. “Moxifloxacin-induced torsades de pointes.” Cardiol J 15, no. 1 (2008): 71–73.
Sherazi S, DiSalle M, Daubert JP, Shah AH. Moxifloxacin-induced torsades de pointes. Cardiol J. 2008;15(1):71–3.
Sherazi, Saadia, et al. “Moxifloxacin-induced torsades de pointes.” Cardiol J, vol. 15, no. 1, 2008, pp. 71–73.
Sherazi S, DiSalle M, Daubert JP, Shah AH. Moxifloxacin-induced torsades de pointes. Cardiol J. 2008;15(1):71–73.
Published In
Cardiol J
EISSN
1898-018X
Publication Date
2008
Volume
15
Issue
1
Start / End Page
71 / 73
Location
Poland
Related Subject Headings
- Torsades de Pointes
- Quinolines
- Moxifloxacin
- Male
- Humans
- Fluoroquinolones
- Electrocardiography
- Cardiovascular System & Hematology
- Aza Compounds
- Anti-Infective Agents