Skip to main content
Journal cover image

The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.

Publication ,  Journal Article
He, YW; Malek, TR
Published in: Crit Rev Immunol
1998

Five cytokines, IL-2, IL-4, IL-7, IL-9, and IL-15, form one group that is characterized by utilizing the common gamma chain (gamma c) as a receptor subunit. Examination of the phenotype of various cytokine or cytokine receptor "knockout" mice demonstrates that these cytokines are critical for normal lymphocyte development and subsequent functional activity of the peripheral immune compartment. This review summarizes the structural and functional properties of each of these five cytokines and their receptors, including the known redundant pathways for each cytokine or receptor. The contribution of these cytokines and receptors will then be considered in detail with respect to regulation of T lymphocyte development and homeostasis of the peripheral T cell compartment.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Crit Rev Immunol

DOI

ISSN

1040-8401

Publication Date

1998

Volume

18

Issue

6

Start / End Page

503 / 524

Location

United States

Related Subject Headings

  • X Chromosome
  • T-Lymphocytes
  • Severe Combined Immunodeficiency
  • Receptors, Interleukin
  • Mice, Mutant Strains
  • Mice
  • Interleukins
  • Immunology
  • Humans
  • Homeostasis
 

Citation

APA
Chicago
ICMJE
MLA
NLM
He, Y. W., & Malek, T. R. (1998). The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis. Crit Rev Immunol, 18(6), 503–524. https://doi.org/10.1615/critrevimmunol.v18.i6.20
He, Y. W., and T. R. Malek. “The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.Crit Rev Immunol 18, no. 6 (1998): 503–24. https://doi.org/10.1615/critrevimmunol.v18.i6.20.
He, Y. W., and T. R. Malek. “The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis.Crit Rev Immunol, vol. 18, no. 6, 1998, pp. 503–24. Pubmed, doi:10.1615/critrevimmunol.v18.i6.20.
Journal cover image

Published In

Crit Rev Immunol

DOI

ISSN

1040-8401

Publication Date

1998

Volume

18

Issue

6

Start / End Page

503 / 524

Location

United States

Related Subject Headings

  • X Chromosome
  • T-Lymphocytes
  • Severe Combined Immunodeficiency
  • Receptors, Interleukin
  • Mice, Mutant Strains
  • Mice
  • Interleukins
  • Immunology
  • Humans
  • Homeostasis