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An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.

Publication ,  Journal Article
Zhang, J; Guo, J; Dzhagalov, I; He, Y-W
Published in: Nat Immunol
September 2005

Fc receptor (FcR)-mediated phagocytosis requires activation of the Rho GTPases Cdc42 and Rac1, but how they are recruited to the FcR is unknown. Here we show that the calcium-promoted Ras inactivator (CAPRI), a Ras GTPase-activating protein, functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis. CAPRI-deficient macrophages had impaired FcgammaR-mediated phagocytosis and oxidative burst, as well as defective activation of Cdc42 and Rac1. CAPRI interacted constitutively with both Cdc42 and Rac1 and translocated to phagocytic cups during FcgammaR-mediated phagocytosis. CAPRI-deficient mice had an impaired innate immune response to bacterial infection. These results suggest that CAPRI provides a link between FcgammaR and Cdc42 and Rac1 and is essential for innate immune responses.

Duke Scholars

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

September 2005

Volume

6

Issue

9

Start / End Page

911 / 919

Location

United States

Related Subject Headings

  • ras GTPase-Activating Proteins
  • rac1 GTP-Binding Protein
  • cdc42 GTP-Binding Protein
  • Toll-Like Receptors
  • Receptors, IgG
  • Receptors, Cell Surface
  • Phosphorylation
  • Phagocytosis
  • Molecular Sequence Data
  • Mice, Knockout
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, J., Guo, J., Dzhagalov, I., & He, Y.-W. (2005). An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Nat Immunol, 6(9), 911–919. https://doi.org/10.1038/ni1232
Zhang, Jun, Jian Guo, Ivan Dzhagalov, and You-Wen He. “An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.Nat Immunol 6, no. 9 (September 2005): 911–19. https://doi.org/10.1038/ni1232.
Zhang J, Guo J, Dzhagalov I, He Y-W. An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Nat Immunol. 2005 Sep;6(9):911–9.
Zhang, Jun, et al. “An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.Nat Immunol, vol. 6, no. 9, Sept. 2005, pp. 911–19. Pubmed, doi:10.1038/ni1232.
Zhang J, Guo J, Dzhagalov I, He Y-W. An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. Nat Immunol. 2005 Sep;6(9):911–919.

Published In

Nat Immunol

DOI

ISSN

1529-2908

Publication Date

September 2005

Volume

6

Issue

9

Start / End Page

911 / 919

Location

United States

Related Subject Headings

  • ras GTPase-Activating Proteins
  • rac1 GTP-Binding Protein
  • cdc42 GTP-Binding Protein
  • Toll-Like Receptors
  • Receptors, IgG
  • Receptors, Cell Surface
  • Phosphorylation
  • Phagocytosis
  • Molecular Sequence Data
  • Mice, Knockout