Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis.
Publication
, Journal Article
Clowse, MEB; Wigley, FM
Published in: J Rheumatol
June 2003
We present a woman with scleroderma who developed multiple ischemic digits after chemotherapy for lung cancer. The ischemia started during treatment with carboplatin and gemcitabine and required amputation of the affected digits. A review of the literature shows that thrombotic episodes coinciding with chemotherapy are not uncommon, though venous thrombosis occurs more frequently than arterial. Scleroderma patients are at particular risk for digital infarction because of their underlying vascular disease and associated Raynaud's phenomenon. This case illustrates the risk of severe digital ischemia and digital loss in patients with scleroderma during chemotherapy with carboplatin and gemcitabine.
Duke Scholars
Published In
J Rheumatol
ISSN
0315-162X
Publication Date
June 2003
Volume
30
Issue
6
Start / End Page
1341 / 1343
Location
Canada
Related Subject Headings
- Scleroderma, Systemic
- Necrosis
- Middle Aged
- Infarction
- Immunosuppressive Agents
- Humans
- Gemcitabine
- Gangrene
- Fingers
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Clowse, M. E. B., & Wigley, F. M. (2003). Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis. J Rheumatol, 30(6), 1341–1343.
Clowse, Megan E. B., and Fredrick M. Wigley. “Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis.” J Rheumatol 30, no. 6 (June 2003): 1341–43.
Clowse MEB, Wigley FM. Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis. J Rheumatol. 2003 Jun;30(6):1341–3.
Clowse, Megan E. B., and Fredrick M. Wigley. “Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis.” J Rheumatol, vol. 30, no. 6, June 2003, pp. 1341–43.
Clowse MEB, Wigley FM. Digital necrosis related to carboplatin and gemcitabine therapy in systemic sclerosis. J Rheumatol. 2003 Jun;30(6):1341–1343.
Published In
J Rheumatol
ISSN
0315-162X
Publication Date
June 2003
Volume
30
Issue
6
Start / End Page
1341 / 1343
Location
Canada
Related Subject Headings
- Scleroderma, Systemic
- Necrosis
- Middle Aged
- Infarction
- Immunosuppressive Agents
- Humans
- Gemcitabine
- Gangrene
- Fingers
- Female