Skip to main content
Journal cover image

Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project.

Publication ,  Journal Article
Nelson, AE; Golightly, YM; Kraus, VB; Stabler, T; Renner, JB; Helmick, CG; Jordan, JM
Published in: Osteoarthritis Cartilage
June 2010

PURPOSE: To test whether serum transforming growth factor-beta 1 (TGF-beta1) predicts incident and progressive hip or knee radiographic OA (rOA). METHODS: Serum TGF-beta1 was measured for 330 participants aged 45 years and older in the Johnston County Osteoarthritis Project, with paired longitudinal films available for 618 hips and 658 knees. Incident and progressive rOA were defined using Kellgren-Lawrence (K-L) grade as well as osteophyte (OST) and joint space narrowing (JSN) scores. Natural logarithm transformation was used to produce near-normal distributions for continuous TGF-beta1 (lnTGF-beta1). Separate multivariable Weibull regression models were used to provide hazard ratios (HRs) for a 1-unit increase lnTGF-beta1 with each rOA outcome, accounting for variable follow-up times and clustering by individual, adjusted for age, race, gender, and body mass index (BMI). Interaction terms were considered statistically significant at P<0.10. RESULTS: The mean (+/-SD) age of the sample was 61.9+/-9.7 years, the mean BMI was 30.3+/-6.9 kg/m(2), with 60.6% women and 42.4% AA. The mean (+/-SD) TGF-beta1 was 17.8+/-6.1 ng/ml; follow-up time was 6.1+/-1.3 years. There were no significant interactions by race or gender. HRs showed no significant relationship between lnTGF-beta1 and incident or progressive rOA, OST, or JSN, at the knee or the hip. CONCLUSIONS: Levels of TGF-beta1 do not predict incident or progressive rOA, OST, or JSN at the hip or knee in this longitudinal, population-based study, making it unlikely that TGF-beta1 will be a robust biomarker for rOA in future studies.

Duke Scholars

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

June 2010

Volume

18

Issue

6

Start / End Page

825 / 829

Location

England

Related Subject Headings

  • White People
  • Transforming Growth Factor beta1
  • Radiography
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Middle Aged
  • Male
  • Longitudinal Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Nelson, A. E., Golightly, Y. M., Kraus, V. B., Stabler, T., Renner, J. B., Helmick, C. G., & Jordan, J. M. (2010). Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage, 18(6), 825–829. https://doi.org/10.1016/j.joca.2010.02.013
Nelson, A. E., Y. M. Golightly, V. B. Kraus, T. Stabler, J. B. Renner, C. G. Helmick, and J. M. Jordan. “Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project.Osteoarthritis Cartilage 18, no. 6 (June 2010): 825–29. https://doi.org/10.1016/j.joca.2010.02.013.
Nelson AE, Golightly YM, Kraus VB, Stabler T, Renner JB, Helmick CG, et al. Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2010 Jun;18(6):825–9.
Nelson, A. E., et al. “Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project.Osteoarthritis Cartilage, vol. 18, no. 6, June 2010, pp. 825–29. Pubmed, doi:10.1016/j.joca.2010.02.013.
Nelson AE, Golightly YM, Kraus VB, Stabler T, Renner JB, Helmick CG, Jordan JM. Serum transforming growth factor-beta 1 is not a robust biomarker of incident and progressive radiographic osteoarthritis at the hip and knee: the Johnston County Osteoarthritis Project. Osteoarthritis Cartilage. 2010 Jun;18(6):825–829.
Journal cover image

Published In

Osteoarthritis Cartilage

DOI

EISSN

1522-9653

Publication Date

June 2010

Volume

18

Issue

6

Start / End Page

825 / 829

Location

England

Related Subject Headings

  • White People
  • Transforming Growth Factor beta1
  • Radiography
  • Proportional Hazards Models
  • Predictive Value of Tests
  • Osteoarthritis, Knee
  • Osteoarthritis, Hip
  • Middle Aged
  • Male
  • Longitudinal Studies