Skip to main content

The Immune Tolerance Network at 10 years: tolerance research at the bedside.

Publication ,  Journal Article
Bluestone, JA; Auchincloss, H; Nepom, GT; Rotrosen, D; St Clair, EW; Turka, LA
Published in: Nat Rev Immunol
November 2010

Immune tolerance-inducing therapies reprogramme immune cells to eliminate pathogenic immune responses while preserving protective immunity. The Immune Tolerance Network (ITN), sponsored by the US National Institutes of Health, was established in 1999 to evaluate new tolerance-inducing therapies and carry out mechanistic studies using a unique interactive approach in partnership with industry, academia and foundations. Ten years later, the ITN has carried out approximately 36 clinical trials and tolerance studies examining innovative tolerogenic approaches in the settings of allergy, autoimmune diseases and organ transplantation. ITN investigators have published more than 80 original research papers based on this work. This Timeline article summarizes the progress and challenges of clinical research in the ITN.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

November 2010

Volume

10

Issue

11

Start / End Page

797 / 803

Location

England

Related Subject Headings

  • United States
  • National Institutes of Health (U.S.)
  • Immunology
  • Immune Tolerance
  • Immune System Diseases
  • Humans
  • Government Programs
  • Clinical Trials as Topic
  • Animals
  • 3204 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bluestone, J. A., Auchincloss, H., Nepom, G. T., Rotrosen, D., St Clair, E. W., & Turka, L. A. (2010). The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol, 10(11), 797–803. https://doi.org/10.1038/nri2869
Bluestone, Jeffrey A., Hugh Auchincloss, Gerald T. Nepom, Daniel Rotrosen, E William St Clair, and Laurence A. Turka. “The Immune Tolerance Network at 10 years: tolerance research at the bedside.Nat Rev Immunol 10, no. 11 (November 2010): 797–803. https://doi.org/10.1038/nri2869.
Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA. The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol. 2010 Nov;10(11):797–803.
Bluestone, Jeffrey A., et al. “The Immune Tolerance Network at 10 years: tolerance research at the bedside.Nat Rev Immunol, vol. 10, no. 11, Nov. 2010, pp. 797–803. Pubmed, doi:10.1038/nri2869.
Bluestone JA, Auchincloss H, Nepom GT, Rotrosen D, St Clair EW, Turka LA. The Immune Tolerance Network at 10 years: tolerance research at the bedside. Nat Rev Immunol. 2010 Nov;10(11):797–803.

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

November 2010

Volume

10

Issue

11

Start / End Page

797 / 803

Location

England

Related Subject Headings

  • United States
  • National Institutes of Health (U.S.)
  • Immunology
  • Immune Tolerance
  • Immune System Diseases
  • Humans
  • Government Programs
  • Clinical Trials as Topic
  • Animals
  • 3204 Immunology