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Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome.

Publication ,  Journal Article
St Clair, EW; Angellilo, JC; Singer, KH
Published in: Arthritis Rheum
January 1992

OBJECTIVE: The potential role of cell adhesion molecules in the pathogenesis of Sjögren's syndrome (SS) was assessed by examining their expression in salivary gland (SGL) tissue. METHODS: Intercellular adhesion molecule type 1 (ICAM-1), lymphocyte function-associated antigen type 1 (LFA-1), LFA-3, CD2, and CD44 expression were determined using indirect immunofluorescence techniques. RESULTS: In inflamed labial SGL tissue, ICAM-1 expression was evident on infiltrating LFA-1+/CD2+/LFA-3+ mononuclear cells, and to a limited extent on SGL acinar epithelial cells adjacent to sites of intense inflammation. CONCLUSION: In SS, the SGL microenvironment is characterized by only a modest up-regulation of ICAM-1 expression on epithelial cells, despite the presence of T cells bearing an activated phenotype.

Duke Scholars

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

January 1992

Volume

35

Issue

1

Start / End Page

62 / 66

Location

United States

Related Subject Headings

  • Up-Regulation
  • Sjogren's Syndrome
  • Salivary Glands
  • Receptors, Lymphocyte Homing
  • Receptors, Immunologic
  • Middle Aged
  • Membrane Glycoproteins
  • Male
  • Lymphocyte Function-Associated Antigen-1
  • Intercellular Adhesion Molecule-1
 

Citation

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St Clair, E. W., Angellilo, J. C., & Singer, K. H. (1992). Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome. Arthritis Rheum, 35(1), 62–66. https://doi.org/10.1002/art.1780350110
St Clair, E. W., J. C. Angellilo, and K. H. Singer. “Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome.Arthritis Rheum 35, no. 1 (January 1992): 62–66. https://doi.org/10.1002/art.1780350110.
St Clair EW, Angellilo JC, Singer KH. Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome. Arthritis Rheum. 1992 Jan;35(1):62–6.
St Clair, E. W., et al. “Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome.Arthritis Rheum, vol. 35, no. 1, Jan. 1992, pp. 62–66. Pubmed, doi:10.1002/art.1780350110.
St Clair EW, Angellilo JC, Singer KH. Expression of cell-adhesion molecules in the salivary gland microenvironment of Sjögren's syndrome. Arthritis Rheum. 1992 Jan;35(1):62–66.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

January 1992

Volume

35

Issue

1

Start / End Page

62 / 66

Location

United States

Related Subject Headings

  • Up-Regulation
  • Sjogren's Syndrome
  • Salivary Glands
  • Receptors, Lymphocyte Homing
  • Receptors, Immunologic
  • Middle Aged
  • Membrane Glycoproteins
  • Male
  • Lymphocyte Function-Associated Antigen-1
  • Intercellular Adhesion Molecule-1