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CTLA4Ig: bridging the basic immunology with clinical application.

Publication ,  Journal Article
Bluestone, JA; St Clair, EW; Turka, LA
Published in: Immunity
March 2006

After a very long and windy road, in December of 2005 the FDA approved CTLA4Ig for the treatment of rheumatoid arthritis. Orencia is the first-in-class antagonist of CD28 costimulation. In this perspective, we discuss the science that led to CTLA4Ig development and the clinical challenges in bringing the drug from the bench to the bedside.

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Published In

Immunity

DOI

ISSN

1074-7613

Publication Date

March 2006

Volume

24

Issue

3

Start / End Page

233 / 238

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Lymphocyte Activation
  • Immunology
  • Immunoconjugates
  • Humans
  • CD40 Ligand
  • CD28 Antigens
  • Animals
  • Abatacept
  • 3204 Immunology
 

Citation

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Chicago
ICMJE
MLA
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Bluestone, J. A., St Clair, E. W., & Turka, L. A. (2006). CTLA4Ig: bridging the basic immunology with clinical application. Immunity, 24(3), 233–238. https://doi.org/10.1016/j.immuni.2006.03.001
Bluestone, Jeffrey A., E William St Clair, and Laurence A. Turka. “CTLA4Ig: bridging the basic immunology with clinical application.Immunity 24, no. 3 (March 2006): 233–38. https://doi.org/10.1016/j.immuni.2006.03.001.
Bluestone JA, St Clair EW, Turka LA. CTLA4Ig: bridging the basic immunology with clinical application. Immunity. 2006 Mar;24(3):233–8.
Bluestone, Jeffrey A., et al. “CTLA4Ig: bridging the basic immunology with clinical application.Immunity, vol. 24, no. 3, Mar. 2006, pp. 233–38. Pubmed, doi:10.1016/j.immuni.2006.03.001.
Bluestone JA, St Clair EW, Turka LA. CTLA4Ig: bridging the basic immunology with clinical application. Immunity. 2006 Mar;24(3):233–238.
Journal cover image

Published In

Immunity

DOI

ISSN

1074-7613

Publication Date

March 2006

Volume

24

Issue

3

Start / End Page

233 / 238

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Lymphocyte Activation
  • Immunology
  • Immunoconjugates
  • Humans
  • CD40 Ligand
  • CD28 Antigens
  • Animals
  • Abatacept
  • 3204 Immunology