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B-lymphocyte contributions to human autoimmune disease.

Publication ,  Journal Article
Yanaba, K; Bouaziz, J-D; Matsushita, T; Magro, CM; St Clair, EW; Tedder, TF
Published in: Immunol Rev
June 2008

Autoimmunity results from abnormal B- and T-cell recognition of self-antigens, which leads to autoantibody production in many cases. Autoantibodies produced by B-cell-derived plasma cells provide diagnostic markers for autoimmunity but also contribute significantly to disease pathogenesis. As discussed in this review, the therapeutic benefit of depleting B cells in mice and humans has refocused attention on B cells and their role in autoimmunity beyond autoantibody production. B cells specifically serve as cellular adjuvants for CD4(+) T-cell activation, while regulatory B cells, including those that produce interleukin-10 (B10 cells), function as negative regulators of inflammatory immune responses. The emerging picture is that B cells, autoantibodies, and T cells are all important components of abnormal immune responses that lead to tissue pathology unique to each autoimmune disease, with their relative contributions changing during disease progression. Autoimmune diseases where B-cell functions are closely correlated with disease activity include systemic lupus erythematosus, rheumatoid arthritis, scleroderma, type 1 diabetes, and multiple sclerosis. Understanding the overlapping roles of B cells as mediators of autoimmune disease will facilitate the development of more precisely directed therapies and combination therapies with broader clinical efficacy than current depletion strategies that remove all B cells.

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Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

June 2008

Volume

223

Start / End Page

284 / 299

Location

England

Related Subject Headings

  • Rituximab
  • Mice
  • Lymphocyte Depletion
  • Lymphocyte Activation
  • Interleukin-10
  • Immunotherapy
  • Immunology
  • Immunologic Memory
  • Humans
  • CD4-Positive T-Lymphocytes
 

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Yanaba, K., Bouaziz, J.-D., Matsushita, T., Magro, C. M., St Clair, E. W., & Tedder, T. F. (2008). B-lymphocyte contributions to human autoimmune disease. Immunol Rev, 223, 284–299. https://doi.org/10.1111/j.1600-065X.2008.00646.x
Yanaba, Koichi, Jean-David Bouaziz, Takashi Matsushita, Cynthia M. Magro, E William St Clair, and Thomas F. Tedder. “B-lymphocyte contributions to human autoimmune disease.Immunol Rev 223 (June 2008): 284–99. https://doi.org/10.1111/j.1600-065X.2008.00646.x.
Yanaba K, Bouaziz J-D, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284–99.
Yanaba, Koichi, et al. “B-lymphocyte contributions to human autoimmune disease.Immunol Rev, vol. 223, June 2008, pp. 284–99. Pubmed, doi:10.1111/j.1600-065X.2008.00646.x.
Yanaba K, Bouaziz J-D, Matsushita T, Magro CM, St Clair EW, Tedder TF. B-lymphocyte contributions to human autoimmune disease. Immunol Rev. 2008 Jun;223:284–299.
Journal cover image

Published In

Immunol Rev

DOI

EISSN

1600-065X

Publication Date

June 2008

Volume

223

Start / End Page

284 / 299

Location

England

Related Subject Headings

  • Rituximab
  • Mice
  • Lymphocyte Depletion
  • Lymphocyte Activation
  • Interleukin-10
  • Immunotherapy
  • Immunology
  • Immunologic Memory
  • Humans
  • CD4-Positive T-Lymphocytes