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Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome.

Publication ,  Journal Article
Simel, DL; St Clair, EW; Adams, J; Greenberg, CS
Published in: Am J Med
September 1987

A 66-year-old man with the lupus anticoagulant-hypoprothrombinemia syndrome was treated with cyclophosphamide and prednisone to correct a factor II deficiency prior to elective major surgery. Whereas the lupus anticoagulant activity persisted, functional factor II levels normalized and he underwent surgery without a bleeding diathesis. Immunosuppressive therapy may temporarily normalize factor II levels in patients with the lupus anticoagulant-hypoprothrombinemia syndrome and reduce the risk of excessive hemorrhage. The disparate response of the lupus anticoagulant and hypoprothrombinemia to immunosuppression suggests that the lupus anticoagulant did not directly cause the hypoprothrombinemia.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

September 1987

Volume

83

Issue

3

Start / End Page

563 / 566

Location

United States

Related Subject Headings

  • Syndrome
  • Risk Factors
  • Preoperative Care
  • Prednisone
  • Postoperative Complications
  • Male
  • Lupus Coagulation Inhibitor
  • Immunosuppressive Agents
  • Hypoprothrombinemias
  • Humans
 

Citation

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Chicago
ICMJE
MLA
NLM
Simel, D. L., St Clair, E. W., Adams, J., & Greenberg, C. S. (1987). Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome. Am J Med, 83(3), 563–566. https://doi.org/10.1016/0002-9343(87)90772-8
Simel, D. L., E. W. St Clair, J. Adams, and C. S. Greenberg. “Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome.Am J Med 83, no. 3 (September 1987): 563–66. https://doi.org/10.1016/0002-9343(87)90772-8.
Simel, D. L., et al. “Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome.Am J Med, vol. 83, no. 3, Sept. 1987, pp. 563–66. Pubmed, doi:10.1016/0002-9343(87)90772-8.
Simel DL, St Clair EW, Adams J, Greenberg CS. Correction of hypoprothrombinemia by immunosuppressive treatment of the lupus anticoagulant-hypoprothrombinemia syndrome. Am J Med. 1987 Sep;83(3):563–566.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

September 1987

Volume

83

Issue

3

Start / End Page

563 / 566

Location

United States

Related Subject Headings

  • Syndrome
  • Risk Factors
  • Preoperative Care
  • Prednisone
  • Postoperative Complications
  • Male
  • Lupus Coagulation Inhibitor
  • Immunosuppressive Agents
  • Hypoprothrombinemias
  • Humans