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Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing.

Publication ,  Journal Article
Smolen, JS; van der Heijde, DM; Aletaha, D; Xu, S; Han, J; Baker, D; St Clair, EW
Published in: Ann Rheum Dis
October 2009

OBJECTIVE: To compare the progression of erosions and joint space narrowing (JSN) in patients with early active rheumatoid arthritis (RA) using data obtained in the "Active-controlled Study of Patients receiving Infliximab for the treatment of Rheumatoid arthritis of Early onset" (ASPIRE) study. METHODS: This was a post hoc analysis of patients in ASPIRE who received placebo plus methotrexate (MTX) or infliximab (3 or 6 mg/kg) plus MTX. Radiographs of the hands (870 patients) and feet (871 patients) were obtained at baseline and week 54 and scored using the van der Heijde/Sharp method. In total, 7160 joints in the placebo plus MTX group and 18,908 joints in the combined infliximab plus MTX group were included in this analysis. RESULTS: At baseline, 83.4% of joints in the placebo plus MTX group had no radiographic damage, 8.5% had only erosions, 4.4% had only JSN and 3.7% had both. The distribution was similar in the infliximab plus MTX group. In the placebo plus MTX group, the majority of joints did not have development or progression of radiographic damage from baseline to week 54; among joints that did have development or progression of damage at week 54, erosions occurred more often than JSN. The same pattern was observed in the infliximab plus MTX group, although the proportions of joints with damage at week 54 were generally larger in the placebo plus MTX group. There was a tendency for joints with existing erosions or JSN to have progression of damage, rather than development of new damage. CONCLUSIONS: Erosions were the predominant type of damage observed in both treatment groups. Erosions and JSN are related but partly independent processes.

Duke Scholars

Published In

Ann Rheum Dis

DOI

EISSN

1468-2060

Publication Date

October 2009

Volume

68

Issue

10

Start / End Page

1535 / 1540

Location

England

Related Subject Headings

  • Young Adult
  • Tumor Necrosis Factor-alpha
  • Radiography
  • Middle Aged
  • Methotrexate
  • Infliximab
  • Humans
  • Hand Joints
  • Foot Joints
  • Follow-Up Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Smolen, J. S., van der Heijde, D. M., Aletaha, D., Xu, S., Han, J., Baker, D., & St Clair, E. W. (2009). Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing. Ann Rheum Dis, 68(10), 1535–1540. https://doi.org/10.1136/ard.2008.094128
Smolen, J. S., D. M. van der Heijde, D. Aletaha, S. Xu, J. Han, D. Baker, and E. W. St Clair. “Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing.Ann Rheum Dis 68, no. 10 (October 2009): 1535–40. https://doi.org/10.1136/ard.2008.094128.
Smolen JS, van der Heijde DM, Aletaha D, Xu S, Han J, Baker D, et al. Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing. Ann Rheum Dis. 2009 Oct;68(10):1535–40.
Smolen, J. S., et al. “Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing.Ann Rheum Dis, vol. 68, no. 10, Oct. 2009, pp. 1535–40. Pubmed, doi:10.1136/ard.2008.094128.
Smolen JS, van der Heijde DM, Aletaha D, Xu S, Han J, Baker D, St Clair EW. Progression of radiographic joint damage in rheumatoid arthritis: independence of erosions and joint space narrowing. Ann Rheum Dis. 2009 Oct;68(10):1535–1540.

Published In

Ann Rheum Dis

DOI

EISSN

1468-2060

Publication Date

October 2009

Volume

68

Issue

10

Start / End Page

1535 / 1540

Location

England

Related Subject Headings

  • Young Adult
  • Tumor Necrosis Factor-alpha
  • Radiography
  • Middle Aged
  • Methotrexate
  • Infliximab
  • Humans
  • Hand Joints
  • Foot Joints
  • Follow-Up Studies