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Novel targeted therapies for autoimmunity.

Publication ,  Journal Article
St Clair, EW
Published in: Curr Opin Immunol
December 2009

The emergence of new targeted therapies is rapidly improving the treatment of autoimmune disease. These drugs have been variably designed to deplete specific T and B cell subsets, interrupt receptor-ligand interactions, and inhibit the activity of inflammatory mediators relevant to immune function. Abatacept, a co-stimulatory blocker, and rituximab, a B cell depleting antibody, are among the approved therapies seeking new indications, while the newer therapies include Fc receptor-non-binding CD3-specific antibodies, IL-12/23 antibodies, an IL-6 receptor antagonist, a sphingosine-1-phosphate agonist, and small molecule inhibitors of intracellular protein kinases. Antigen-specific therapies are in their infancy, but the latest results administering glutamic acid dehydrogenase peptide to type 1 diabetics are promising. In the future, treatment strategies may increasingly explore the use of drug combinations acting at multiple sites of aberrant immunoregulation to achieve disease quiescence and immune tolerance.

Duke Scholars

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Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

December 2009

Volume

21

Issue

6

Start / End Page

648 / 657

Location

England

Related Subject Headings

  • Receptors, Immunologic
  • Lymphocytes
  • Immunology
  • Immune Tolerance
  • Humans
  • Cytokines
  • Autoimmune Diseases
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

APA
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ICMJE
MLA
NLM
St Clair, E. W. (2009). Novel targeted therapies for autoimmunity. Curr Opin Immunol, 21(6), 648–657. https://doi.org/10.1016/j.coi.2009.09.008
St Clair, E William. “Novel targeted therapies for autoimmunity.Curr Opin Immunol 21, no. 6 (December 2009): 648–57. https://doi.org/10.1016/j.coi.2009.09.008.
St Clair EW. Novel targeted therapies for autoimmunity. Curr Opin Immunol. 2009 Dec;21(6):648–57.
St Clair, E. William. “Novel targeted therapies for autoimmunity.Curr Opin Immunol, vol. 21, no. 6, Dec. 2009, pp. 648–57. Pubmed, doi:10.1016/j.coi.2009.09.008.
St Clair EW. Novel targeted therapies for autoimmunity. Curr Opin Immunol. 2009 Dec;21(6):648–657.
Journal cover image

Published In

Curr Opin Immunol

DOI

EISSN

1879-0372

Publication Date

December 2009

Volume

21

Issue

6

Start / End Page

648 / 657

Location

England

Related Subject Headings

  • Receptors, Immunologic
  • Lymphocytes
  • Immunology
  • Immune Tolerance
  • Humans
  • Cytokines
  • Autoimmune Diseases
  • Animals
  • 3204 Immunology
  • 1107 Immunology