Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.
Publication
, Journal Article
St Clair, EW; Burch, JA; Saitta, M
Published in: Arthritis Rheum
September 1994
OBJECTIVE: To compare patterns of Ro autoantigen recognition in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). METHODS: Sera were tested by enzyme-linked immunosorbent assay (ELISA) and immunoprecipitation for reactivity with recombinant human 60-kd and 52-kd Ro proteins. RESULTS: SLE and primary SS sera exhibited similar patterns of reactivity with the recombinant 52-kd protein. However, a greater proportion of sera from primary SS patients than from SLE patients did not react with recombinant 60-kd protein in ELISA yet precipitated its translation product in solution-phase assays. CONCLUSION: Disease state can influence recognition of the recombinant 60-kd Ro antigen.
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Published In
Arthritis Rheum
DOI
ISSN
0004-3591
Publication Date
September 1994
Volume
37
Issue
9
Start / End Page
1373 / 1379
Location
United States
Related Subject Headings
- Ribonucleoproteins
- Recombinant Proteins
- RNA, Small Cytoplasmic
- Molecular Weight
- Immunoblotting
- Humans
- Enzyme-Linked Immunosorbent Assay
- Electrophoresis, Polyacrylamide Gel
- Cross Reactions
- Autoantigens
Citation
APA
Chicago
ICMJE
MLA
NLM
St Clair, E. W., Burch, J. A., & Saitta, M. (1994). Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens. Arthritis Rheum, 37(9), 1373–1379. https://doi.org/10.1002/art.1780370916
St Clair, E. W., J. A. Burch, and M. Saitta. “Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.” Arthritis Rheum 37, no. 9 (September 1994): 1373–79. https://doi.org/10.1002/art.1780370916.
St Clair EW, Burch JA, Saitta M. Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens. Arthritis Rheum. 1994 Sep;37(9):1373–9.
St Clair, E. W., et al. “Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.” Arthritis Rheum, vol. 37, no. 9, Sept. 1994, pp. 1373–79. Pubmed, doi:10.1002/art.1780370916.
St Clair EW, Burch JA, Saitta M. Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens. Arthritis Rheum. 1994 Sep;37(9):1373–1379.
Published In
Arthritis Rheum
DOI
ISSN
0004-3591
Publication Date
September 1994
Volume
37
Issue
9
Start / End Page
1373 / 1379
Location
United States
Related Subject Headings
- Ribonucleoproteins
- Recombinant Proteins
- RNA, Small Cytoplasmic
- Molecular Weight
- Immunoblotting
- Humans
- Enzyme-Linked Immunosorbent Assay
- Electrophoresis, Polyacrylamide Gel
- Cross Reactions
- Autoantigens