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Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.

Publication ,  Journal Article
St Clair, EW; Burch, JA; Saitta, M
Published in: Arthritis Rheum
September 1994

OBJECTIVE: To compare patterns of Ro autoantigen recognition in primary Sjögren's syndrome (SS) and systemic lupus erythematosus (SLE). METHODS: Sera were tested by enzyme-linked immunosorbent assay (ELISA) and immunoprecipitation for reactivity with recombinant human 60-kd and 52-kd Ro proteins. RESULTS: SLE and primary SS sera exhibited similar patterns of reactivity with the recombinant 52-kd protein. However, a greater proportion of sera from primary SS patients than from SLE patients did not react with recombinant 60-kd protein in ELISA yet precipitated its translation product in solution-phase assays. CONCLUSION: Disease state can influence recognition of the recombinant 60-kd Ro antigen.

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Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

September 1994

Volume

37

Issue

9

Start / End Page

1373 / 1379

Location

United States

Related Subject Headings

  • Ribonucleoproteins
  • Recombinant Proteins
  • RNA, Small Cytoplasmic
  • Molecular Weight
  • Immunoblotting
  • Humans
  • Enzyme-Linked Immunosorbent Assay
  • Electrophoresis, Polyacrylamide Gel
  • Cross Reactions
  • Autoantigens
 

Citation

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St Clair, E. W., Burch, J. A., & Saitta, M. (1994). Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens. Arthritis Rheum, 37(9), 1373–1379. https://doi.org/10.1002/art.1780370916
St Clair, E. W., J. A. Burch, and M. Saitta. “Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.Arthritis Rheum 37, no. 9 (September 1994): 1373–79. https://doi.org/10.1002/art.1780370916.
St Clair EW, Burch JA, Saitta M. Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens. Arthritis Rheum. 1994 Sep;37(9):1373–9.
St Clair, E. W., et al. “Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens.Arthritis Rheum, vol. 37, no. 9, Sept. 1994, pp. 1373–79. Pubmed, doi:10.1002/art.1780370916.
St Clair EW, Burch JA, Saitta M. Specificity of autoantibodies for recombinant 60-kd and 52-kd Ro autoantigens. Arthritis Rheum. 1994 Sep;37(9):1373–1379.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

September 1994

Volume

37

Issue

9

Start / End Page

1373 / 1379

Location

United States

Related Subject Headings

  • Ribonucleoproteins
  • Recombinant Proteins
  • RNA, Small Cytoplasmic
  • Molecular Weight
  • Immunoblotting
  • Humans
  • Enzyme-Linked Immunosorbent Assay
  • Electrophoresis, Polyacrylamide Gel
  • Cross Reactions
  • Autoantigens