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Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis.

Publication ,  Journal Article
Tomasson, G; Lavalley, M; Tanriverdi, K; Finkielman, JD; Davis, JC; Hoffman, GS; McCune, WJ; St Clair, EW; Specks, U; Spiera, R; Stone, JH ...
Published in: J Rheumatol
June 2011

OBJECTIVE: There remains a need for biomarkers to guide therapy in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Our objective was to determine whether measures of platelet activation or inflammation are associated with disease activity in Wegener's granulomatosis (WG). METHODS: Study subjects were participants in a clinical trial. Soluble CD40 ligand (sCD40L), C-reactive protein, interleukin 6 (IL-6), IL-8, monocyte chemoattractant protein 1 (MCP-1), P-selectin, vascular endothelial growth factor, and proteinase 3 (PR3)-specific ANCA were measured by ELISA using plasma samples obtained at baseline (active disease), at remission, and prior to, during, and after first flares. Disease activity was assessed by the Birmingham Vasculitis Activity Score for WG (BVAS/WG). Association of biomarkers with disease activity was determined with conditional logistic and linear regression. RESULTS: Over a mean followup of 27 months, 180 subjects underwent 2044 visits; markers were measured in 563 samples. Longitudinally, all markers other than IL-6 were associated with disease activity. The strongest associations for active disease at baseline versus remission were observed for sCD40L (OR 4.72, 95% CI 2.47-9.03), P-selectin (OR 6.26, 95% CI 2.78-14.10), PR3-ANCA (OR 9.41, 4.03-21.99), and inversely for MCP-1 (OR 0.36, 95% CI 0.22-0.57). BVAS/WG increased by 0.80 (95% CI 0.44-1.16), 0.83 (95% CI 0.42-1.25), and 0.81 (95% CI 0.48-1.15) per unit-increase in PR3-ANCA, sCD40L, and P-selectin, respectively; and decreased by 1.54 (95% CI 0.96-2.12) per unit-increase in MCP-1. CONCLUSION: Cytokines arising from within the circulation, including those of platelet activation, correlate with disease activity in WG.

Duke Scholars

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

June 2011

Volume

38

Issue

6

Start / End Page

1048 / 1054

Location

Canada

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Severity of Illness Index
  • Retrospective Studies
  • Platelet Activation
  • P-Selectin
  • Myeloblastin
  • Interleukin-8
  • Inflammation
  • Humans
  • Granulomatosis with Polyangiitis
 

Citation

APA
Chicago
ICMJE
MLA
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Tomasson, G., Lavalley, M., Tanriverdi, K., Finkielman, J. D., Davis, J. C., Hoffman, G. S., … Wegener’s Granulomatosis Etanercept Trial (WGET) Research Group, . (2011). Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. J Rheumatol, 38(6), 1048–1054. https://doi.org/10.3899/jrheum.100735
Tomasson, Gunnar, Michael Lavalley, Kahraman Tanriverdi, Javier D. Finkielman, John C. Davis, Gary S. Hoffman, W Joseph McCune, et al. “Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis.J Rheumatol 38, no. 6 (June 2011): 1048–54. https://doi.org/10.3899/jrheum.100735.
Tomasson G, Lavalley M, Tanriverdi K, Finkielman JD, Davis JC, Hoffman GS, et al. Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. J Rheumatol. 2011 Jun;38(6):1048–54.
Tomasson, Gunnar, et al. “Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis.J Rheumatol, vol. 38, no. 6, June 2011, pp. 1048–54. Pubmed, doi:10.3899/jrheum.100735.
Tomasson G, Lavalley M, Tanriverdi K, Finkielman JD, Davis JC, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Stone JH, Freedman JE, Merkel PA, Wegener’s Granulomatosis Etanercept Trial (WGET) Research Group. Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. J Rheumatol. 2011 Jun;38(6):1048–1054.

Published In

J Rheumatol

DOI

EISSN

1499-2752

Publication Date

June 2011

Volume

38

Issue

6

Start / End Page

1048 / 1054

Location

Canada

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Severity of Illness Index
  • Retrospective Studies
  • Platelet Activation
  • P-Selectin
  • Myeloblastin
  • Interleukin-8
  • Inflammation
  • Humans
  • Granulomatosis with Polyangiitis