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N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus.

Publication ,  Journal Article
Cooper, GS; Treadwell, EL; Dooley, MA; St Clair, EW; Gilkeson, GS; Taylor, JA
Published in: J Rheumatol
January 2004

OBJECTIVE: To examine the association between N-acetyl transferase (NAT) genotype (NAT1 and NAT2) and risk of developing systemic lupus erythematosus (SLE). METHODS: DNA samples were collected from 243 recently diagnosed cases and 298 controls enrolled in a population based case-control study conducted in 60 counties in North Carolina and South Carolina, USA. RESULTS: There was no association between SLE and NAT1 genotype (OR 0.96, 95% CI 0.65, 1.4 for the presence of a *10 allele) or NAT2 genotype (OR 1.1, 95% CI 0.73, 1.6 for the slow- compared with fast-acetylation genotype). We saw some evidence of interaction between NAT genotypes and use of hair dyes (a source of arylamines), with higher risk seen among hair dye users who had both the *10 NAT1 allele and the NAT2 slow-acetylation genotype (OR 2.9, 95% CI 1.2, 6.9 in this subgroup compared with all others). CONCLUSION: Our results suggest that although there is little overall association between NAT genotypes and risk of developing SLE, the interaction between NAT1 and NAT2 and specific exposures such as hair dyes may be important. This finding highlights the need to consider exposure when assessing genetic susceptibility.

Duke Scholars

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

January 2004

Volume

31

Issue

1

Start / End Page

76 / 80

Location

Canada

Related Subject Headings

  • Risk Factors
  • Prevalence
  • Male
  • Lupus Erythematosus, Systemic
  • Isoenzymes
  • Humans
  • Hair Dyes
  • Genotype
  • Genetic Predisposition to Disease
  • Female
 

Citation

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MLA
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Cooper, G. S., Treadwell, E. L., Dooley, M. A., St Clair, E. W., Gilkeson, G. S., & Taylor, J. A. (2004). N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus. J Rheumatol, 31(1), 76–80.
Cooper, Glinda S., Edward L. Treadwell, Mary Anne Dooley, E William St Clair, Gary S. Gilkeson, and Jack A. Taylor. “N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus.J Rheumatol 31, no. 1 (January 2004): 76–80.
Cooper GS, Treadwell EL, Dooley MA, St Clair EW, Gilkeson GS, Taylor JA. N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus. J Rheumatol. 2004 Jan;31(1):76–80.
Cooper, Glinda S., et al. “N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus.J Rheumatol, vol. 31, no. 1, Jan. 2004, pp. 76–80.
Cooper GS, Treadwell EL, Dooley MA, St Clair EW, Gilkeson GS, Taylor JA. N-acetyl transferase genotypes in relation to risk of developing systemic lupus erythematosus. J Rheumatol. 2004 Jan;31(1):76–80.

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

January 2004

Volume

31

Issue

1

Start / End Page

76 / 80

Location

Canada

Related Subject Headings

  • Risk Factors
  • Prevalence
  • Male
  • Lupus Erythematosus, Systemic
  • Isoenzymes
  • Humans
  • Hair Dyes
  • Genotype
  • Genetic Predisposition to Disease
  • Female