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Anti-La antibodies.

Publication ,  Journal Article
St Clair, EW
Published in: Rheum Dis Clin North Am
May 1992

Anti-La antibodies usually occur in sera with anti-Ro antibodies and represent important serologic markers of Sjögren's syndrome and neonatal lupus erythematosus. In addition to their diagnostic and prognostic significance, anti-La antibodies have proved valuable reagents for molecularly characterizing its antigenic target, which is a 47 kD ribonucleoprotein located in the nucleus and cytoplasm of mammalian cells. The isotype distribution and fine specificity of the anti-La response as well as its associations with HLA-DR and DQ loci suggest that these autoantibodies arise by a T cell-dependent, antigen-driven mechanism. Further insights into the mechanisms of anti-La production in humans may be gained by studying experimental animal models that develop these antibodies spontaneously or through induction by various immunization protocols.

Duke Scholars

Published In

Rheum Dis Clin North Am

ISSN

0889-857X

Publication Date

May 1992

Volume

18

Issue

2

Start / End Page

359 / 376

Location

United States

Related Subject Headings

  • Sjogren's Syndrome
  • SS-B Antigen
  • Ribonucleoproteins
  • Lupus Erythematosus, Systemic
  • Immunochemistry
  • Humans
  • HLA Antigens
  • Autoantigens
  • Arthritis & Rheumatology
  • Antibody Specificity
 

Citation

APA
Chicago
ICMJE
MLA
NLM
St Clair, E. W. (1992). Anti-La antibodies. Rheum Dis Clin North Am, 18(2), 359–376.
St Clair, E. W. “Anti-La antibodies.Rheum Dis Clin North Am 18, no. 2 (May 1992): 359–76.
St Clair EW. Anti-La antibodies. Rheum Dis Clin North Am. 1992 May;18(2):359–76.
St Clair, E. W. “Anti-La antibodies.Rheum Dis Clin North Am, vol. 18, no. 2, May 1992, pp. 359–76.
St Clair EW. Anti-La antibodies. Rheum Dis Clin North Am. 1992 May;18(2):359–376.
Journal cover image

Published In

Rheum Dis Clin North Am

ISSN

0889-857X

Publication Date

May 1992

Volume

18

Issue

2

Start / End Page

359 / 376

Location

United States

Related Subject Headings

  • Sjogren's Syndrome
  • SS-B Antigen
  • Ribonucleoproteins
  • Lupus Erythematosus, Systemic
  • Immunochemistry
  • Humans
  • HLA Antigens
  • Autoantigens
  • Arthritis & Rheumatology
  • Antibody Specificity