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Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.

Publication ,  Journal Article
Merkel, PA; Lo, GH; Holbrook, JT; Tibbs, AK; Allen, NB; Davis, JC; Hoffman, GS; McCune, WJ; St Clair, EW; Specks, U; Spiera, R; Petri, M ...
Published in: Ann Intern Med
April 19, 2005

BACKGROUND: Venous thrombotic events (VTEs) have been observed in Wegener granulomatosis, but the incidence rate is not known. OBJECTIVE: To measure the incidence of VTEs in patients with Wegener granulomatosis. DESIGN: Prospective, observational cohort study. SETTING: A multicenter, randomized, double-blind, placebo-controlled treatment trial for Wegener granulomatosis. PATIENTS: 180 patients with Wegener granulomatosis enrolled during periods of active disease. MEASUREMENTS: Venous thrombotic events (deep venous thromboses or pulmonary emboli) were documented and confirmed prospectively. Incidence rates were calculated on the basis of time to first VTE. RESULTS: Thirteen patients had VTEs before enrollment. During 228 person-years of prospective follow-up, 16 VTEs occurred in 167 patients with no history of VTE. Median time from enrollment to VTE for patients with an event was 2.1 months. The incidence of VTE among patients with Wegener granulomatosis was 7.0 per 100 person-years (95% CI, 4.0 to 11.4). LIMITATIONS: Although prospectively recorded, screening for VTEs did not occur. CONCLUSIONS: The incidence rate of VTEs in Wegener granulomatosis is high when compared with available rates in the general population, patients with lupus, and patients with rheumatoid arthritis. These results have important implications for clinical care of patients with Wegener granulomatosis.

Duke Scholars

Published In

Ann Intern Med

DOI

EISSN

1539-3704

Publication Date

April 19, 2005

Volume

142

Issue

8

Start / End Page

620 / 626

Location

United States

Related Subject Headings

  • Venous Thrombosis
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Granulomatosis with Polyangiitis
  • General & Internal Medicine
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Merkel, P. A., Lo, G. H., Holbrook, J. T., Tibbs, A. K., Allen, N. B., Davis, J. C., … Wegener’s Granulomatosis Etanercept Trial Research Group, . (2005). Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study. Ann Intern Med, 142(8), 620–626. https://doi.org/10.7326/0003-4819-142-8-200505030-00011
Merkel, Peter A., Grace H. Lo, Janet T. Holbrook, Andrea K. Tibbs, Nancy B. Allen, John C. Davis, Gary S. Hoffman, et al. “Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.Ann Intern Med 142, no. 8 (April 19, 2005): 620–26. https://doi.org/10.7326/0003-4819-142-8-200505030-00011.
Merkel, Peter A., et al. “Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study.Ann Intern Med, vol. 142, no. 8, Apr. 2005, pp. 620–26. Pubmed, doi:10.7326/0003-4819-142-8-200505030-00011.
Merkel PA, Lo GH, Holbrook JT, Tibbs AK, Allen NB, Davis JC, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Petri M, Stone JH, Wegener’s Granulomatosis Etanercept Trial Research Group. Brief communication: high incidence of venous thrombotic events among patients with Wegener granulomatosis: the Wegener's Clinical Occurrence of Thrombosis (WeCLOT) Study. Ann Intern Med. 2005 Apr 19;142(8):620–626.

Published In

Ann Intern Med

DOI

EISSN

1539-3704

Publication Date

April 19, 2005

Volume

142

Issue

8

Start / End Page

620 / 626

Location

United States

Related Subject Headings

  • Venous Thrombosis
  • Risk Factors
  • Prospective Studies
  • Middle Aged
  • Male
  • Incidence
  • Humans
  • Granulomatosis with Polyangiitis
  • General & Internal Medicine
  • Female