Skip to main content
Journal cover image

Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease.

Publication ,  Journal Article
Goel, N; Ulrich, DT; St Clair, EW; Fleming, JA; Lynch, DH; Seldin, MF
Published in: Arthritis Rheum
December 1995

OBJECTIVE: To determine whether elevated soluble Fas/APO-1 (sFas/APO-1) levels are associated with either autoimmune disease or evidence of flares in autoimmune disease. METHODS: Thirty-seven serum samples were retrospectively obtained from normal controls and patients with laboratory evidence of autoimmune disease activity. These samples were assayed for sFas/APO-1 levels by an enzyme-linked immunosorbent assay, and hospital medical records were retrospectively reviewed for clinical and laboratory characteristics of the patients. RESULTS: Soluble Fas/APO-1 levels did not correlate with clinical diagnoses or laboratory abnormalities. The mean and range of sFas/APO-1 levels were similar in systemic lupus erythematosus patients (including those with active disease), patients with other autoimmune diseases, and normal controls. CONCLUSION: These data strongly suggest that measurement of sFas/APO-1 levels is unlikely to hold clinical value or play a role in the pathogenesis of autoimmune disease.

Duke Scholars

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

December 1995

Volume

38

Issue

12

Start / End Page

1738 / 1743

Location

United States

Related Subject Headings

  • fas Receptor
  • Solubility
  • Severity of Illness Index
  • Retrospective Studies
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Female
  • Enzyme-Linked Immunosorbent Assay
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Goel, N., Ulrich, D. T., St Clair, E. W., Fleming, J. A., Lynch, D. H., & Seldin, M. F. (1995). Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. Arthritis Rheum, 38(12), 1738–1743. https://doi.org/10.1002/art.1780381206
Goel, N., D. T. Ulrich, E. W. St Clair, J. A. Fleming, D. H. Lynch, and M. F. Seldin. “Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease.Arthritis Rheum 38, no. 12 (December 1995): 1738–43. https://doi.org/10.1002/art.1780381206.
Goel N, Ulrich DT, St Clair EW, Fleming JA, Lynch DH, Seldin MF. Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. Arthritis Rheum. 1995 Dec;38(12):1738–43.
Goel, N., et al. “Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease.Arthritis Rheum, vol. 38, no. 12, Dec. 1995, pp. 1738–43. Pubmed, doi:10.1002/art.1780381206.
Goel N, Ulrich DT, St Clair EW, Fleming JA, Lynch DH, Seldin MF. Lack of correlation between serum soluble Fas/APO-1 levels and autoimmune disease. Arthritis Rheum. 1995 Dec;38(12):1738–1743.
Journal cover image

Published In

Arthritis Rheum

DOI

ISSN

0004-3591

Publication Date

December 1995

Volume

38

Issue

12

Start / End Page

1738 / 1743

Location

United States

Related Subject Headings

  • fas Receptor
  • Solubility
  • Severity of Illness Index
  • Retrospective Studies
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Humans
  • Female
  • Enzyme-Linked Immunosorbent Assay