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The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event.

Publication ,  Journal Article
Sebastian, JK; Voetsch, B; Stone, JH; Romay-Penabad, Z; Lo, GH; Allen, NB; Davis, JC; Hoffman, GS; McCune, WJ; St Clair, EW; Specks, U ...
Published in: J Rheumatol
December 2007

OBJECTIVE: Venous thrombotic events (VTE), including both deep venous thrombosis and pulmonary emboli, are now recognized as an important complication of Wegener's granulomatosis (WG), but the mechanism(s) of this occurrence is unclear. The frequency of anticardiolipin antibodies (aCL), anti-beta2-glycoprotein antibodies (anti-beta2-GP), and several genetic hypercoagulable factors were examined in a large cohort of patients with WG. METHODS: One hundred eighty patients with active WG had serum and DNA samples collected upon entry into a clinical trial. Of the 180 patients, 29 patients had VTE -- 13 before trial entry, 16 during trial. aCL (IgG, IgM, and IgA) and anti-beta2-GP (IgG and IgM) were evaluated in 176 patients. Factor V Leiden (FVL), the prothrombin gene mutation (G20210A, PGM), and methylenetetrahydrofolate reductase (MTHFR) gene mutation were tested in the 29 patients with thrombotic events, and 36 patients without. RESULTS: aCL occurred with increased frequencies in patients with WG when compared to the general population (1%-5%): 12% had aCL and 3% had anti-beta2-GP. There was no difference in the prevalences of aCL or anti-beta2-GP based on clotting status. The prevalence of the genetic hypercoagulable factors examined in patients with WG was comparable to the reported rates in the general population. CONCLUSION: Although the incidence of clinically significant VTE is increased in patients with WG, this increased risk is not explained by increased prevalences of aCL, anti-beta2-GP, FVL, or mutations in PGM or MTHFR. These observations suggest a need to search for new genetic or acquired prothrombotic abnormalities to account for the increased thrombotic event rate in patients with active WG.

Duke Scholars

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

December 2007

Volume

34

Issue

12

Start / End Page

2446 / 2450

Location

Canada

Related Subject Headings

  • Venous Thrombosis
  • Thrombophilia
  • Risk Factors
  • Pulmonary Embolism
  • Mutation
  • Male
  • Humans
  • Granulomatosis with Polyangiitis
  • Genetic Predisposition to Disease
  • Female
 

Citation

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Sebastian, J. K., Voetsch, B., Stone, J. H., Romay-Penabad, Z., Lo, G. H., Allen, N. B., … Wegener’s Granulomatosis Etanercept Trial Research Group, . (2007). The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event. J Rheumatol, 34(12), 2446–2450.
Sebastian, Jodi K., Barbara Voetsch, John H. Stone, Zurina Romay-Penabad, Grace H. Lo, Nancy B. Allen, John C. Davis, et al. “The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event.J Rheumatol 34, no. 12 (December 2007): 2446–50.
Sebastian JK, Voetsch B, Stone JH, Romay-Penabad Z, Lo GH, Allen NB, Davis JC, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Loscalzo J, Pierangeli S, Merkel PA, Wegener’s Granulomatosis Etanercept Trial Research Group. The frequency of anticardiolipin antibodies and genetic mutations associated with hypercoagulability among patients with Wegener's granulomatosis with and without history of a thrombotic event. J Rheumatol. 2007 Dec;34(12):2446–2450.

Published In

J Rheumatol

ISSN

0315-162X

Publication Date

December 2007

Volume

34

Issue

12

Start / End Page

2446 / 2450

Location

Canada

Related Subject Headings

  • Venous Thrombosis
  • Thrombophilia
  • Risk Factors
  • Pulmonary Embolism
  • Mutation
  • Male
  • Humans
  • Granulomatosis with Polyangiitis
  • Genetic Predisposition to Disease
  • Female