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CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States.

Publication ,  Journal Article
Parks, CG; Hudson, LL; Cooper, GS; Dooley, MA; Treadwell, EL; St Clair, EW; Gilkeson, GS; Pandey, JP
Published in: Lupus
2004

Cytotoxic lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activation, and may help to limit T cell response under conditions of inflammation. Genetic variability in CTLA-4 has been implicated in the development of several autoimmune diseases. Some studies have described associations between CTLA-4 polymorphisms and systemic lupus erythematosus (SLE), but findings have been inconsistent. We examined polymorphisms in the CTLA-4 gene promoter region (-1722T/C, -1661 A/G, -318C/T) and exon I (+49G/A) with respect to SLE in a population-based case-control study in the southeastern US. Genotypes from 230 recently diagnosed cases and 276 controls were examined separately for African-Americans and whites. We observed no overall associations between SLE and the four CTLA-4 polymorphisms examined. Subgroup analyses revealed effect modification by age for the presence of the -1661G allele, yielding a significant positive association with SLE in younger (<35 years) African-Americans (OR = 3.3). CTLA-4 genotypes also interacted with HLA-DR2 and GM allotype to contribute to risk of SLE. These findings suggest allelic variation in this region of CTLA4 is not a major independent risk factor for SLE, but may contribute to risk of disease in younger African-Americans or in the presence of certain immunogenetic markers.

Duke Scholars

Published In

Lupus

DOI

ISSN

0961-2033

Publication Date

2004

Volume

13

Issue

10

Start / End Page

784 / 791

Location

England

Related Subject Headings

  • White People
  • Southeastern United States
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Gm Allotypes
  • Humans
  • HLA-DR2 Antigen
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Parks, C. G., Hudson, L. L., Cooper, G. S., Dooley, M. A., Treadwell, E. L., St Clair, E. W., … Pandey, J. P. (2004). CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States. Lupus, 13(10), 784–791. https://doi.org/10.1191/0961203304lu1085oa
Parks, C. G., L. L. Hudson, G. S. Cooper, M. A. Dooley, E. L. Treadwell, E. W. St Clair, G. S. Gilkeson, and J. P. Pandey. “CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States.Lupus 13, no. 10 (2004): 784–91. https://doi.org/10.1191/0961203304lu1085oa.
Parks CG, Hudson LL, Cooper GS, Dooley MA, Treadwell EL, St Clair EW, et al. CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States. Lupus. 2004;13(10):784–91.
Parks, C. G., et al. “CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States.Lupus, vol. 13, no. 10, 2004, pp. 784–91. Pubmed, doi:10.1191/0961203304lu1085oa.
Parks CG, Hudson LL, Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Pandey JP. CTLA-4 gene polymorphisms and systemic lupus erythematosus in a population-based study of whites and African-Americans in the southeastern United States. Lupus. 2004;13(10):784–791.
Journal cover image

Published In

Lupus

DOI

ISSN

0961-2033

Publication Date

2004

Volume

13

Issue

10

Start / End Page

784 / 791

Location

England

Related Subject Headings

  • White People
  • Southeastern United States
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Gm Allotypes
  • Humans
  • HLA-DR2 Antigen