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Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States.

Publication ,  Journal Article
Parks, CG; Cooper, GS; Dooley, MA; Treadwell, EL; St Clair, EW; Gilkeson, GS; Pandey, JP
Published in: Ann Rheum Dis
January 2004

BACKGROUND: Interleukin (IL)1alpha and IL1beta, and their endogenous receptor antagonist (IL1Ra), have been related to the pathology of systemic lupus erythematosus (SLE), but the role of IL1 polymorphisms in the aetiology of SLE is unknown. OBJECTIVE: To examine polymorphisms at IL1alpha -889(C-->T), IL1alpha +4845(C-->T), IL1beta -511(C-->T), IL1beta +3953(G-->T), and IL1Ra (86 bp VNTR) in a population based study of SLE in North Carolina and South Carolina. METHODS: Genotypes from 230 cases who met ACR classification criteria, and from 275 controls matched for age, sex, and state, were analysed separately for African Americans and whites. Odds ratios (ORs) were estimated by logistic regression models for each locus alone and also after adjusting for polymorphisms at adjacent loci. RESULTS: An increased risk of SLE for the IL1alpha -889C/C genotype compared with carriage of the -889T allele was found in both African Americans (OR = 3.1, p = 0.001) and whites (OR = 2.9, p = 0.005). In African Americans, carriage of the IL1beta -511T allele was associated with a higher risk of SLE than carriage of the -511C/C genotype (OR = 2.4, p = 0.017), independent of variation at IL1alpha -889. CONCLUSIONS: The observed associations support the hypothesis that genetic variation in IL1 is involved in the aetiology of SLE and merit further investigation.

Duke Scholars

Published In

Ann Rheum Dis

DOI

ISSN

0003-4967

Publication Date

January 2004

Volume

63

Issue

1

Start / End Page

91 / 94

Location

England

Related Subject Headings

  • White People
  • Southeastern United States
  • Sialoglycoproteins
  • Polymorphism, Genetic
  • Multigene Family
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Logistic Models
  • Interleukin-1
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Parks, C. G., Cooper, G. S., Dooley, M. A., Treadwell, E. L., St Clair, E. W., Gilkeson, G. S., & Pandey, J. P. (2004). Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States. Ann Rheum Dis, 63(1), 91–94. https://doi.org/10.1136/ard.2003.007336
Parks, C. G., G. S. Cooper, M. A. Dooley, E. L. Treadwell, E. W. St Clair, G. S. Gilkeson, and J. P. Pandey. “Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States.Ann Rheum Dis 63, no. 1 (January 2004): 91–94. https://doi.org/10.1136/ard.2003.007336.
Parks CG, Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, et al. Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States. Ann Rheum Dis. 2004 Jan;63(1):91–4.
Parks, C. G., et al. “Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States.Ann Rheum Dis, vol. 63, no. 1, Jan. 2004, pp. 91–94. Pubmed, doi:10.1136/ard.2003.007336.
Parks CG, Cooper GS, Dooley MA, Treadwell EL, St Clair EW, Gilkeson GS, Pandey JP. Systemic lupus erythematosus and genetic variation in the interleukin 1 gene cluster: a population based study in the southeastern United States. Ann Rheum Dis. 2004 Jan;63(1):91–94.

Published In

Ann Rheum Dis

DOI

ISSN

0003-4967

Publication Date

January 2004

Volume

63

Issue

1

Start / End Page

91 / 94

Location

England

Related Subject Headings

  • White People
  • Southeastern United States
  • Sialoglycoproteins
  • Polymorphism, Genetic
  • Multigene Family
  • Middle Aged
  • Male
  • Lupus Erythematosus, Systemic
  • Logistic Models
  • Interleukin-1