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Immunoglobulin GM and KM allotypes in systemic lupus erythematosus.

Publication ,  Journal Article
Pandey, JP; Cooper, GS; Treadwell, EL; Gilkeson, GS; St Clair, EW; Dooley, MA
Published in: Exp Clin Immunogenet
2001

Genetic variation in immunoglobulin gamma (GM) and kappa (KM) chains was associated with systemic lupus erythematosus (SLE) in some studies. However, the data are conflicting, and only one study examined associations in African-Americans. We examined GM and KM allotypes, by race, in a population-based case-control study of SLE. Sera from patients (n = 222) and controls (n = 273) were typed for GM and KM allotypes by a hemagglutination inhibition method. GM phenotypes were not significantly associated with SLE in African-Americans or Caucasians. However, the frequency of KM phenotypes in Caucasian patients was significantly different from that in controls (p = 0.032). KM3,3 was associated with an increased risk, whereas KM1,3 was associated with a lower relative risk of SLE. In African-Americans, however, the pattern of associations with KM phenotypes differed from that in Caucasians, and the overall difference between patients and controls was not statistically significant.

Duke Scholars

Published In

Exp Clin Immunogenet

DOI

ISSN

0254-9670

Publication Date

2001

Volume

18

Issue

3

Start / End Page

117 / 122

Location

Switzerland

Related Subject Headings

  • White People
  • Phenotype
  • Male
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunoglobulin Gm Allotypes
  • Immunoglobulin Allotypes
  • Immunogenetics
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pandey, J. P., Cooper, G. S., Treadwell, E. L., Gilkeson, G. S., St Clair, E. W., & Dooley, M. A. (2001). Immunoglobulin GM and KM allotypes in systemic lupus erythematosus. Exp Clin Immunogenet, 18(3), 117–122. https://doi.org/10.1159/000049190
Pandey, J. P., G. S. Cooper, E. L. Treadwell, G. S. Gilkeson, E. W. St Clair, and M. A. Dooley. “Immunoglobulin GM and KM allotypes in systemic lupus erythematosus.Exp Clin Immunogenet 18, no. 3 (2001): 117–22. https://doi.org/10.1159/000049190.
Pandey JP, Cooper GS, Treadwell EL, Gilkeson GS, St Clair EW, Dooley MA. Immunoglobulin GM and KM allotypes in systemic lupus erythematosus. Exp Clin Immunogenet. 2001;18(3):117–22.
Pandey, J. P., et al. “Immunoglobulin GM and KM allotypes in systemic lupus erythematosus.Exp Clin Immunogenet, vol. 18, no. 3, 2001, pp. 117–22. Pubmed, doi:10.1159/000049190.
Pandey JP, Cooper GS, Treadwell EL, Gilkeson GS, St Clair EW, Dooley MA. Immunoglobulin GM and KM allotypes in systemic lupus erythematosus. Exp Clin Immunogenet. 2001;18(3):117–122.

Published In

Exp Clin Immunogenet

DOI

ISSN

0254-9670

Publication Date

2001

Volume

18

Issue

3

Start / End Page

117 / 122

Location

Switzerland

Related Subject Headings

  • White People
  • Phenotype
  • Male
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunoglobulin Gm Allotypes
  • Immunoglobulin Allotypes
  • Immunogenetics
  • Humans
  • Female