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Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study.

Publication ,  Journal Article
Pathak, S; Kratochvil, CJ; Rogers, GM; Silva, S; Vitiello, B; Weller, EB; March, JS
Published in: Current psychiatry reports
December 2005

Adolescents with major depressive disorder (MDD), their families and clinicians experience significant challenges when weighing the potential risks versus benefits of available choices in the treatment of MDD. Although MDD is highly prevalent in adolescents and is associated with marked suffering, impairment and risk of suicide, the scientific data regarding the safety and efficacy of treatments for pediatric depression are limited. Controlled clinical trials have provided support for the use of psychotherapy and fluoxetine for the treatment of pediatric depression, but until recently no information on the comparative efficacy of these recommended interventions alone or in combination was available. The Treatment for Adolescents with Depression Study provides a very important therapeutic advance in the field by convincingly showing that combination treatment with cognitive behavioral therapy and fluoxetine has the best benefit to risk ratio for adolescents with moderate to severe depression, and is superior to monotherapy. Moreover, the study results confirm that fluoxetine alone is effective in the treatment of depressed adolescents.

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Published In

Current psychiatry reports

DOI

EISSN

1535-1645

ISSN

1523-3812

Publication Date

December 2005

Volume

7

Issue

6

Start / End Page

429 / 434

Related Subject Headings

  • Treatment Outcome
  • Suicide
  • Severity of Illness Index
  • Selective Serotonin Reuptake Inhibitors
  • Risk Factors
  • Psychiatry
  • Humans
  • Fluoxetine
  • Depressive Disorder, Major
  • Combined Modality Therapy
 

Citation

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Pathak, S., Kratochvil, C. J., Rogers, G. M., Silva, S., Vitiello, B., Weller, E. B., & March, J. S. (2005). Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study. Current Psychiatry Reports, 7(6), 429–434. https://doi.org/10.1007/s11920-005-0063-y
Pathak, Sanjeev, Christopher J. Kratochvil, Gregory M. Rogers, Susan Silva, Benedetto Vitiello, Elizabeth B. Weller, and John S. March. “Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study.Current Psychiatry Reports 7, no. 6 (December 2005): 429–34. https://doi.org/10.1007/s11920-005-0063-y.
Pathak S, Kratochvil CJ, Rogers GM, Silva S, Vitiello B, Weller EB, et al. Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study. Current psychiatry reports. 2005 Dec;7(6):429–34.
Pathak, Sanjeev, et al. “Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study.Current Psychiatry Reports, vol. 7, no. 6, Dec. 2005, pp. 429–34. Epmc, doi:10.1007/s11920-005-0063-y.
Pathak S, Kratochvil CJ, Rogers GM, Silva S, Vitiello B, Weller EB, March JS. Comparative efficacy of cognitive behavioral therapy, fluoxetine, and their combination in depressed adolescents: initial lessons from the treatment for adolescents with depression study. Current psychiatry reports. 2005 Dec;7(6):429–434.
Journal cover image

Published In

Current psychiatry reports

DOI

EISSN

1535-1645

ISSN

1523-3812

Publication Date

December 2005

Volume

7

Issue

6

Start / End Page

429 / 434

Related Subject Headings

  • Treatment Outcome
  • Suicide
  • Severity of Illness Index
  • Selective Serotonin Reuptake Inhibitors
  • Risk Factors
  • Psychiatry
  • Humans
  • Fluoxetine
  • Depressive Disorder, Major
  • Combined Modality Therapy