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JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.

Publication ,  Journal Article
Homsy, JG; Jasper, H; Peralta, XG; Wu, H; Kiehart, DP; Bohmann, D
Published in: Developmental dynamics : an official publication of the American Association of Anatomists
February 2006

Epithelial movements are key morphogenetic events in animal development. They are driven by multiple mechanisms, including signal-dependent changes in cytoskeletal organization and in cell adhesion. Such processes must be controlled precisely and coordinated to accurately sculpt the three-dimensional form of the developing organism. By observing the Drosophila epidermis during embryonic development using confocal time-lapse microscopy, we have investigated how signaling through the Jun-N-terminal kinase (JNK) pathway governs the tissue sheet movements that result in dorsal closure (DC). We find that JNK controls the polymerization of actin into a cable at the epidermal leading edge as previously suggested, as well as the joining (zipping) of the contralateral epithelial cell sheets. Here, we show that zipping is mediated by regulation of the integrins myospheroid and scab. Our data demonstrate that JNK signaling regulates a set of target genes that cooperate to facilitate epithelial movement and closure.

Duke Scholars

Published In

Developmental dynamics : an official publication of the American Association of Anatomists

DOI

EISSN

1097-0177

ISSN

1058-8388

Publication Date

February 2006

Volume

235

Issue

2

Start / End Page

427 / 434

Related Subject Headings

  • Signal Transduction
  • Mutation
  • JNK Mitogen-Activated Protein Kinases
  • Integrins
  • Gene Expression Regulation, Developmental
  • Embryonic Development
  • Drosophila melanogaster
  • Developmental Biology
  • Animals
  • Actins
 

Citation

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MLA
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Homsy, J. G., Jasper, H., Peralta, X. G., Wu, H., Kiehart, D. P., & Bohmann, D. (2006). JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Developmental Dynamics : An Official Publication of the American Association of Anatomists, 235(2), 427–434. https://doi.org/10.1002/dvdy.20649
Homsy, Jason G., Heinrich Jasper, Xomalin G. Peralta, Hai Wu, Daniel P. Kiehart, and Dirk Bohmann. “JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.Developmental Dynamics : An Official Publication of the American Association of Anatomists 235, no. 2 (February 2006): 427–34. https://doi.org/10.1002/dvdy.20649.
Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D. JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 2006 Feb;235(2):427–34.
Homsy, Jason G., et al. “JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis.Developmental Dynamics : An Official Publication of the American Association of Anatomists, vol. 235, no. 2, Feb. 2006, pp. 427–34. Epmc, doi:10.1002/dvdy.20649.
Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D. JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 2006 Feb;235(2):427–434.
Journal cover image

Published In

Developmental dynamics : an official publication of the American Association of Anatomists

DOI

EISSN

1097-0177

ISSN

1058-8388

Publication Date

February 2006

Volume

235

Issue

2

Start / End Page

427 / 434

Related Subject Headings

  • Signal Transduction
  • Mutation
  • JNK Mitogen-Activated Protein Kinases
  • Integrins
  • Gene Expression Regulation, Developmental
  • Embryonic Development
  • Drosophila melanogaster
  • Developmental Biology
  • Animals
  • Actins