Skip to main content
Journal cover image

Emergent properties during dorsal closure in Drosophila morphogenesis.

Publication ,  Journal Article
Peralta, XG; Toyama, Y; Kiehart, DP; Edwards, GS
Published in: Physical Biology
2008

Dorsal closure is an essential stage of Drosophila development that is a model system for research in morphogenesis and biological physics. Dorsal closure involves an orchestrated interplay between gene expression and cell activities that produce shape changes, exert forces and mediate tissue dynamics. We investigate the dynamics of dorsal closure based on confocal microscopic measurements of cell shortening in living embryos. During the mid-stages of dorsal closure we find that there are fluctuations in the width of the leading edge cells but the time-averaged analysis of measurements indicate that there is essentially no net shortening of cells in the bulk of the leading edge, that contraction predominantly occurs at the canthi as part of the process for zipping together the two leading edges of epidermis and that the rate constant for zipping correlates with the rate of movement of the leading edges. We characterize emergent properties that regulate dorsal closure, i.e., a velocity governor and the coordination and synchronization of tissue dynamics.

Duke Scholars

Published In

Physical Biology

ISSN

1478-3975

Publication Date

2008

Volume

5

Issue

1

Start / End Page

15004

Location

england

Related Subject Headings

  • Biophysics
  • 51 Physical sciences
  • 40 Engineering
  • 31 Biological sciences
  • 09 Engineering
  • 06 Biological Sciences
  • 02 Physical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Peralta, X. G., Toyama, Y., Kiehart, D. P., & Edwards, G. S. (2008). Emergent properties during dorsal closure in Drosophila morphogenesis. Physical Biology, 5(1), 15004.
Peralta, X. G., Y. Toyama, D. P. Kiehart, and G. S. Edwards. “Emergent properties during dorsal closure in Drosophila morphogenesis.Physical Biology 5, no. 1 (2008): 15004.
Peralta XG, Toyama Y, Kiehart DP, Edwards GS. Emergent properties during dorsal closure in Drosophila morphogenesis. Physical Biology. 2008;5(1):15004.
Peralta, X. G., et al. “Emergent properties during dorsal closure in Drosophila morphogenesis.Physical Biology, vol. 5, no. 1, 2008, p. 15004.
Peralta XG, Toyama Y, Kiehart DP, Edwards GS. Emergent properties during dorsal closure in Drosophila morphogenesis. Physical Biology. 2008;5(1):15004.
Journal cover image

Published In

Physical Biology

ISSN

1478-3975

Publication Date

2008

Volume

5

Issue

1

Start / End Page

15004

Location

england

Related Subject Headings

  • Biophysics
  • 51 Physical sciences
  • 40 Engineering
  • 31 Biological sciences
  • 09 Engineering
  • 06 Biological Sciences
  • 02 Physical Sciences