Apoptotic force and tissue dynamics during Drosophila embryogenesis.
Understanding cell morphogenesis during metazoan development requires knowledge of how cells and the extracellular matrix produce and respond to forces. We investigated how apoptosis, which remodels tissue by eliminating supernumerary cells, also contributes forces to a tissue (the amnioserosa) that promotes cell-sheet fusion (dorsal closure) in the Drosophila embryo. We showed that expression in the amnioserosa of proteins that suppress or enhance apoptosis slows or speeds dorsal closure, respectively. These changes correlate with the forces produced by the amnioserosa and the rate of seam formation between the cell sheets (zipping), key processes that contribute to closure. This apoptotic force is used by the embryo to drive cell-sheet movements during development, a role not classically attributed to apoptosis.
Duke Scholars
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Related Subject Headings
- Morphogenesis
- Microscopy, Confocal
- General Science & Technology
- Female
- Epithelium
- Epithelial Cells
- Epidermis
- Epidermal Cells
- Embryonic Development
- Embryo, Nonmammalian
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Morphogenesis
- Microscopy, Confocal
- General Science & Technology
- Female
- Epithelium
- Epithelial Cells
- Epidermis
- Epidermal Cells
- Embryonic Development
- Embryo, Nonmammalian