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Apoptotic force and tissue dynamics during Drosophila embryogenesis.

Publication ,  Journal Article
Toyama, Y; Peralta, XG; Wells, AR; Kiehart, DP; Edwards, GS
Published in: Science (New York, N.Y.)
September 2008

Understanding cell morphogenesis during metazoan development requires knowledge of how cells and the extracellular matrix produce and respond to forces. We investigated how apoptosis, which remodels tissue by eliminating supernumerary cells, also contributes forces to a tissue (the amnioserosa) that promotes cell-sheet fusion (dorsal closure) in the Drosophila embryo. We showed that expression in the amnioserosa of proteins that suppress or enhance apoptosis slows or speeds dorsal closure, respectively. These changes correlate with the forces produced by the amnioserosa and the rate of seam formation between the cell sheets (zipping), key processes that contribute to closure. This apoptotic force is used by the embryo to drive cell-sheet movements during development, a role not classically attributed to apoptosis.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

September 2008

Volume

321

Issue

5896

Start / End Page

1683 / 1686

Related Subject Headings

  • Morphogenesis
  • Microscopy, Confocal
  • General Science & Technology
  • Female
  • Epithelium
  • Epithelial Cells
  • Epidermis
  • Epidermal Cells
  • Embryonic Development
  • Embryo, Nonmammalian
 

Citation

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Toyama, Y., Peralta, X. G., Wells, A. R., Kiehart, D. P., & Edwards, G. S. (2008). Apoptotic force and tissue dynamics during Drosophila embryogenesis. Science (New York, N.Y.), 321(5896), 1683–1686. https://doi.org/10.1126/science.1157052
Toyama, Yusuke, Xomalin G. Peralta, Adrienne R. Wells, Daniel P. Kiehart, and Glenn S. Edwards. “Apoptotic force and tissue dynamics during Drosophila embryogenesis.Science (New York, N.Y.) 321, no. 5896 (September 2008): 1683–86. https://doi.org/10.1126/science.1157052.
Toyama Y, Peralta XG, Wells AR, Kiehart DP, Edwards GS. Apoptotic force and tissue dynamics during Drosophila embryogenesis. Science (New York, NY). 2008 Sep;321(5896):1683–6.
Toyama, Yusuke, et al. “Apoptotic force and tissue dynamics during Drosophila embryogenesis.Science (New York, N.Y.), vol. 321, no. 5896, Sept. 2008, pp. 1683–86. Epmc, doi:10.1126/science.1157052.
Toyama Y, Peralta XG, Wells AR, Kiehart DP, Edwards GS. Apoptotic force and tissue dynamics during Drosophila embryogenesis. Science (New York, NY). 2008 Sep;321(5896):1683–1686.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

September 2008

Volume

321

Issue

5896

Start / End Page

1683 / 1686

Related Subject Headings

  • Morphogenesis
  • Microscopy, Confocal
  • General Science & Technology
  • Female
  • Epithelium
  • Epithelial Cells
  • Epidermis
  • Epidermal Cells
  • Embryonic Development
  • Embryo, Nonmammalian