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Microparticles as autoadjuvants in the pathogenesis of SLE.

Publication ,  Journal Article
Pisetsky, DS; Lipsky, PE
Published in: Nat Rev Rheumatol
June 2010

Nucleic acids represent the main source of autoantigens in systemic lupus erythematosus (SLE). DNA and RNA can exit the cell during cell death and, in the extracellular space, can be immunostimulatory. Also extracellularly, DNA and RNA can be incorporated into microparticles (MPs)-small, membrane-bound vesicles released from dying cells by blebbing. We suggest that MPs display autoantigens, such as RNA and DNA, in a highly immunostimulatory manner, enabling them to function as autoadjuvants. In the bone marrow, nucleic-acid-containing MP autoadjuvants might induce B-cell tolerance, whereas in the periphery, they might stimulate mature B cells that have escaped central tolerance. Indeed, because MP autoadjuvants can trigger several receptors, they could effectively provide apoptotic or activating signals to B cells. We would therefore advance the idea that a model for SLE based on MP autoadjuvants can provide a new paradigm to elucidate the mechanisms by which DNA and RNA affect the immune system and critically influence B-cell fate.

Duke Scholars

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

June 2010

Volume

6

Issue

6

Start / End Page

368 / 372

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • RNA
  • Lupus Erythematosus, Systemic
  • Immune Tolerance
  • Humans
  • DNA
  • Cell-Derived Microparticles
  • B-Lymphocytes
  • Autoantigens
  • Antibodies, Antinuclear
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Pisetsky, D. S., & Lipsky, P. E. (2010). Microparticles as autoadjuvants in the pathogenesis of SLE. Nat Rev Rheumatol, 6(6), 368–372. https://doi.org/10.1038/nrrheum.2010.66
Pisetsky, David S., and Peter E. Lipsky. “Microparticles as autoadjuvants in the pathogenesis of SLE.Nat Rev Rheumatol 6, no. 6 (June 2010): 368–72. https://doi.org/10.1038/nrrheum.2010.66.
Pisetsky DS, Lipsky PE. Microparticles as autoadjuvants in the pathogenesis of SLE. Nat Rev Rheumatol. 2010 Jun;6(6):368–72.
Pisetsky, David S., and Peter E. Lipsky. “Microparticles as autoadjuvants in the pathogenesis of SLE.Nat Rev Rheumatol, vol. 6, no. 6, June 2010, pp. 368–72. Pubmed, doi:10.1038/nrrheum.2010.66.
Pisetsky DS, Lipsky PE. Microparticles as autoadjuvants in the pathogenesis of SLE. Nat Rev Rheumatol. 2010 Jun;6(6):368–372.

Published In

Nat Rev Rheumatol

DOI

EISSN

1759-4804

Publication Date

June 2010

Volume

6

Issue

6

Start / End Page

368 / 372

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • RNA
  • Lupus Erythematosus, Systemic
  • Immune Tolerance
  • Humans
  • DNA
  • Cell-Derived Microparticles
  • B-Lymphocytes
  • Autoantigens
  • Antibodies, Antinuclear