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Inhibition of in vitro NZB antibody responses by cyclosporine.

Publication ,  Journal Article
Pisetsky, DS
Published in: Clin Exp Immunol
January 1988

To characterize functional abnormalities of B cells in murine autoimmunity, the effect of cyclosporine (CsA) on antibody responses of NZB and control BALB/c spleen cells was investigated in vitro. Under conditions of high cell density, both NZB and BALB/c spleen cells spontaneously produced IgM and IgM anti-DNA, although NZB responses were greater in magnitude and demonstrated at lower cell densities. In cultures at 5 x 10(6) cells/ml, CsA preferentially inhibited anti-DNA production by cells of both strains. However, to achieve similar levels of inhibition of both responses, significantly higher concentrations of CsA were required for cultures of NZB compared to BALB/c cells. These results support previous experiments indicating enhanced sensitivity to CsA as a pharmacological marker of autoantibody producing B cells. They further suggest that B cell activation in certain forms of autoimmunity may be associated with decreased sensitivity to immunosuppressive agents.

Duke Scholars

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

January 1988

Volume

71

Issue

1

Start / End Page

155 / 158

Location

England

Related Subject Headings

  • Mice, Inbred NZB
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunoglobulin M
  • Female
  • Dose-Response Relationship, Immunologic
  • DNA
 

Citation

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ICMJE
MLA
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Pisetsky, D. S. (1988). Inhibition of in vitro NZB antibody responses by cyclosporine. Clin Exp Immunol, 71(1), 155–158.
Pisetsky, D. S. “Inhibition of in vitro NZB antibody responses by cyclosporine.Clin Exp Immunol 71, no. 1 (January 1988): 155–58.
Pisetsky DS. Inhibition of in vitro NZB antibody responses by cyclosporine. Clin Exp Immunol. 1988 Jan;71(1):155–8.
Pisetsky, D. S. “Inhibition of in vitro NZB antibody responses by cyclosporine.Clin Exp Immunol, vol. 71, no. 1, Jan. 1988, pp. 155–58.
Pisetsky DS. Inhibition of in vitro NZB antibody responses by cyclosporine. Clin Exp Immunol. 1988 Jan;71(1):155–158.
Journal cover image

Published In

Clin Exp Immunol

ISSN

0009-9104

Publication Date

January 1988

Volume

71

Issue

1

Start / End Page

155 / 158

Location

England

Related Subject Headings

  • Mice, Inbred NZB
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunoglobulin M
  • Female
  • Dose-Response Relationship, Immunologic
  • DNA