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Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.

Publication ,  Journal Article
St Clair, EW; Query, CC; Bentley, R; Keene, JD; Polisson, RP; Allen, NB; Caldwell, DS; Rice, JR; Cox, C; Pisetsky, DS
Published in: Clin Immunol Immunopathol
February 1990

To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.

Duke Scholars

Published In

Clin Immunol Immunopathol

DOI

ISSN

0090-1229

Publication Date

February 1990

Volume

54

Issue

2

Start / End Page

266 / 280

Location

United States

Related Subject Headings

  • snRNP Core Proteins
  • Ribonucleoproteins
  • Recombinant Fusion Proteins
  • RNA, Small Nuclear
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunodiffusion
  • Humans
  • Enzyme-Linked Immunosorbent Assay
  • Connective Tissue Diseases
 

Citation

APA
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ICMJE
MLA
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St Clair, E. W., Query, C. C., Bentley, R., Keene, J. D., Polisson, R. P., Allen, N. B., … Pisetsky, D. S. (1990). Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. Clin Immunol Immunopathol, 54(2), 266–280. https://doi.org/10.1016/0090-1229(90)90088-8
St Clair, E. W., C. C. Query, R. Bentley, J. D. Keene, R. P. Polisson, N. B. Allen, D. S. Caldwell, J. R. Rice, C. Cox, and D. S. Pisetsky. “Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.Clin Immunol Immunopathol 54, no. 2 (February 1990): 266–80. https://doi.org/10.1016/0090-1229(90)90088-8.
St Clair EW, Query CC, Bentley R, Keene JD, Polisson RP, Allen NB, et al. Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. Clin Immunol Immunopathol. 1990 Feb;54(2):266–80.
St Clair, E. W., et al. “Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus.Clin Immunol Immunopathol, vol. 54, no. 2, Feb. 1990, pp. 266–80. Pubmed, doi:10.1016/0090-1229(90)90088-8.
St Clair EW, Query CC, Bentley R, Keene JD, Polisson RP, Allen NB, Caldwell DS, Rice JR, Cox C, Pisetsky DS. Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. Clin Immunol Immunopathol. 1990 Feb;54(2):266–280.

Published In

Clin Immunol Immunopathol

DOI

ISSN

0090-1229

Publication Date

February 1990

Volume

54

Issue

2

Start / End Page

266 / 280

Location

United States

Related Subject Headings

  • snRNP Core Proteins
  • Ribonucleoproteins
  • Recombinant Fusion Proteins
  • RNA, Small Nuclear
  • Lupus Erythematosus, Systemic
  • Immunology
  • Immunodiffusion
  • Humans
  • Enzyme-Linked Immunosorbent Assay
  • Connective Tissue Diseases