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Autoantibodies and their significance.

Publication ,  Journal Article
Pisetsky, DS
Published in: Curr Opin Rheumatol
September 1993

In systemic lupus erythematosus, autoantibodies have structural features that indicate in vivo selection by a T cell-dependent, antigen-driven process. The B-cell component of these responses resembles a conventional antibody response, whereas the T-cell component may involve diverse stimulatory mechanisms and levels of regulatory control. Characterizing T-cell epitopes of autoantigens has been difficult because these molecules are ubiquitous and exist inside the cells as multicomponent, macromolecular complexes. Autoantibodies can mediate disease manifestations by various mechanisms, with variable region structures determining the pattern and severity of tissue injury.

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Published In

Curr Opin Rheumatol

DOI

ISSN

1040-8711

Publication Date

September 1993

Volume

5

Issue

5

Start / End Page

549 / 556

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Nuclear Proteins
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Variable Region
  • Humans
  • B-Lymphocytes
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antibodies, Antinuclear
  • Animals
 

Citation

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Pisetsky, D. S. (1993). Autoantibodies and their significance. Curr Opin Rheumatol, 5(5), 549–556. https://doi.org/10.1097/00002281-199305050-00002
Pisetsky, D. S. “Autoantibodies and their significance.Curr Opin Rheumatol 5, no. 5 (September 1993): 549–56. https://doi.org/10.1097/00002281-199305050-00002.
Pisetsky DS. Autoantibodies and their significance. Curr Opin Rheumatol. 1993 Sep;5(5):549–56.
Pisetsky, D. S. “Autoantibodies and their significance.Curr Opin Rheumatol, vol. 5, no. 5, Sept. 1993, pp. 549–56. Pubmed, doi:10.1097/00002281-199305050-00002.
Pisetsky DS. Autoantibodies and their significance. Curr Opin Rheumatol. 1993 Sep;5(5):549–556.

Published In

Curr Opin Rheumatol

DOI

ISSN

1040-8711

Publication Date

September 1993

Volume

5

Issue

5

Start / End Page

549 / 556

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Nuclear Proteins
  • Lupus Erythematosus, Systemic
  • Immunoglobulin Variable Region
  • Humans
  • B-Lymphocytes
  • Autoantibodies
  • Arthritis & Rheumatology
  • Antibodies, Antinuclear
  • Animals