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Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.

Publication ,  Journal Article
St Clair, EW; Talal, N; Moutsopoulos, HM; Ballester, A; Zerva, L; Keene, JD; Pisetsky, DS
Published in: J Autoimmun
August 1989

To investigate patterns of autoreactivity in Sjögren's syndrome, the epitope specificity of anti-La antibodies was determined using recombinant antigens bearing sequences of the amino, middle, and carboxyl portions of the La molecule. Sera from patients with primary as well as secondary Sjögren's syndrome reacted with all three fragments, although the magnitude of the responses varied markedly among individuals. Furthermore, the proportion of antibody binding directed to the different La epitopes showed considerable individual variations, but these patterns were not correlated with specific clinical manifestations. These results suggest that quantitative and qualitative aspects of anti-La responses in Sjögren's syndrome are determined by factors distinct from those determining the clinical expression of disease.

Duke Scholars

Published In

J Autoimmun

DOI

ISSN

0896-8411

Publication Date

August 1989

Volume

2

Issue

4

Start / End Page

335 / 344

Location

England

Related Subject Headings

  • Sjogren's Syndrome
  • SS-B Antigen
  • Ribonucleoproteins
  • Recombinant Fusion Proteins
  • Immunology
  • Epitopes
  • Connective Tissue Diseases
  • Autoimmune Diseases
  • Autoantigens
  • Antibody Specificity
 

Citation

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MLA
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St Clair, E. W., Talal, N., Moutsopoulos, H. M., Ballester, A., Zerva, L., Keene, J. D., & Pisetsky, D. S. (1989). Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome. J Autoimmun, 2(4), 335–344. https://doi.org/10.1016/0896-8411(89)90161-3
St Clair, E. W., N. Talal, H. M. Moutsopoulos, A. Ballester, L. Zerva, J. D. Keene, and D. S. Pisetsky. “Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.J Autoimmun 2, no. 4 (August 1989): 335–44. https://doi.org/10.1016/0896-8411(89)90161-3.
St Clair EW, Talal N, Moutsopoulos HM, Ballester A, Zerva L, Keene JD, et al. Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome. J Autoimmun. 1989 Aug;2(4):335–44.
St Clair, E. W., et al. “Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome.J Autoimmun, vol. 2, no. 4, Aug. 1989, pp. 335–44. Pubmed, doi:10.1016/0896-8411(89)90161-3.
St Clair EW, Talal N, Moutsopoulos HM, Ballester A, Zerva L, Keene JD, Pisetsky DS. Epitope specificity of anti-La antibodies from patients with Sjögren's syndrome. J Autoimmun. 1989 Aug;2(4):335–344.
Journal cover image

Published In

J Autoimmun

DOI

ISSN

0896-8411

Publication Date

August 1989

Volume

2

Issue

4

Start / End Page

335 / 344

Location

England

Related Subject Headings

  • Sjogren's Syndrome
  • SS-B Antigen
  • Ribonucleoproteins
  • Recombinant Fusion Proteins
  • Immunology
  • Epitopes
  • Connective Tissue Diseases
  • Autoimmune Diseases
  • Autoantigens
  • Antibody Specificity