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Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma.

Publication ,  Journal Article
Cohen, SL; Lee, PP; Herndon, LW; Challa, P; Overbury, O; Allingham, RR
Published in: Arch Ophthalmol
January 2003

BACKGROUND: Vascular phenomena are considered important to optic nerve and visual field progression in open-angle glaucoma (OAG). A recently described formulation, the Pressure Attenuation Index (PAI), links arteriolar caliber variations to pressure loss along the retinal arteriolar system. OBJECTIVE: To examine whether the PAI could predict ocular hypertension (OHT) progression to OAG. METHODS: The PAI was calculated for 27 eyes of 14 patients with OHT using initial and final digitized optic disc photographs taken during a follow-up interval of 5 to 18 years. Serial stereo color disc photographs and visual fields were analyzed to determine progression. RESULTS: At baseline, the arteriolar tree of 8 subjects with OHT that progressed to OAG (n = 8 eyes) demonstrated a 45.8% greater mean PAI value than that of 7 subjects who did not progress (n = 7 eyes) (mean +/- SEM, 5.31 +/- 0.93 vs 3.64 +/- 0.34; r = 0.83). Progression was independent of baseline cup-disc ratio. The PAI values of subjects with stable OHT remained stable after a median follow-up interval of 12.0 years. The PAI values of subjects with OHT that progressed demonstrated a further increase of 19.97% +/- 11.24% during a median follow-up period of 6.0 years. CONCLUSIONS: The results support the hypothesis that low end-arteriolar pressure predicts the progression from OHT to OAG. The PAI provides a new, early, reproducible, and physiological method to study vascular phenomena in glaucoma.

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Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

January 2003

Volume

121

Issue

1

Start / End Page

33 / 38

Location

United States

Related Subject Headings

  • Visual Fields
  • Retinal Artery
  • Photography
  • Optic Disk
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Intraocular Pressure
  • Image Processing, Computer-Assisted
  • Humans
  • Glaucoma, Open-Angle
 

Citation

APA
Chicago
ICMJE
MLA
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Cohen, S. L., Lee, P. P., Herndon, L. W., Challa, P., Overbury, O., & Allingham, R. R. (2003). Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma. Arch Ophthalmol, 121(1), 33–38. https://doi.org/10.1001/archopht.121.1.33
Cohen, Shawn L., Paul P. Lee, Leon W. Herndon, Pratap Challa, Olga Overbury, and R Rand Allingham. “Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma.Arch Ophthalmol 121, no. 1 (January 2003): 33–38. https://doi.org/10.1001/archopht.121.1.33.
Cohen SL, Lee PP, Herndon LW, Challa P, Overbury O, Allingham RR. Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma. Arch Ophthalmol. 2003 Jan;121(1):33–8.
Cohen, Shawn L., et al. “Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma.Arch Ophthalmol, vol. 121, no. 1, Jan. 2003, pp. 33–38. Pubmed, doi:10.1001/archopht.121.1.33.
Cohen SL, Lee PP, Herndon LW, Challa P, Overbury O, Allingham RR. Using the arteriolar Pressure Attenuation Index to predict ocular hypertension progression to open-angle glaucoma. Arch Ophthalmol. 2003 Jan;121(1):33–38.

Published In

Arch Ophthalmol

DOI

ISSN

0003-9950

Publication Date

January 2003

Volume

121

Issue

1

Start / End Page

33 / 38

Location

United States

Related Subject Headings

  • Visual Fields
  • Retinal Artery
  • Photography
  • Optic Disk
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Intraocular Pressure
  • Image Processing, Computer-Assisted
  • Humans
  • Glaucoma, Open-Angle