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Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia.

Publication ,  Journal Article
McDonald, AG; Yang, K; Roberts, HR; Monroe, DM; Hoffman, M
Published in: Blood
February 15, 2008

Healing of skin wounds is delayed in hemophilia B (HB) mice. HB mice do not bleed excessively at wounding, yet rebleed hours to days later. Tissue factor (TF) expression is up-regulated by inflammatory cytokines and has been linked to angiogenesis. We hypothesized that impaired thrombin generation in HB leads to impaired TF expression following injury. Punch biopsies were placed on wild-type (WT) and HB mice. Tissues from wound sites were immunostained for TF. Blood vessels are normally surrounded by a coat of pericytes expressing TF. Surprisingly, within a day after wounding TF disappeared from around nearby vessels; returning after 8 days in WT and 10 days in HB mice. The granulation tissue filling the wound during healing also lacked TF around angiogenic vessels. Thus, perivascular TF expression is down-regulated during wound healing. This may prevent thrombosis of neovessels during angiogenesis but renders hemophiliacs vulnerable to hemorrhage during healing.

Duke Scholars

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

February 15, 2008

Volume

111

Issue

4

Start / End Page

2046 / 2048

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Wound Healing
  • Thromboplastin
  • Skin
  • Mice, Knockout
  • Mice
  • Immunology
  • Humans
  • Hemophilia B
  • Gene Expression Regulation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
McDonald, A. G., Yang, K., Roberts, H. R., Monroe, D. M., & Hoffman, M. (2008). Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. Blood, 111(4), 2046–2048. https://doi.org/10.1182/blood-2007-05-092916
McDonald, Anna G., Katie Yang, Harold R. Roberts, Dougald M. Monroe, and Maureane Hoffman. “Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia.Blood 111, no. 4 (February 15, 2008): 2046–48. https://doi.org/10.1182/blood-2007-05-092916.
McDonald AG, Yang K, Roberts HR, Monroe DM, Hoffman M. Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. Blood. 2008 Feb 15;111(4):2046–8.
McDonald, Anna G., et al. “Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia.Blood, vol. 111, no. 4, Feb. 2008, pp. 2046–48. Pubmed, doi:10.1182/blood-2007-05-092916.
McDonald AG, Yang K, Roberts HR, Monroe DM, Hoffman M. Perivascular tissue factor is down-regulated following cutaneous wounding: implications for bleeding in hemophilia. Blood. 2008 Feb 15;111(4):2046–2048.

Published In

Blood

DOI

ISSN

0006-4971

Publication Date

February 15, 2008

Volume

111

Issue

4

Start / End Page

2046 / 2048

Location

United States

Related Subject Headings

  • Wounds and Injuries
  • Wound Healing
  • Thromboplastin
  • Skin
  • Mice, Knockout
  • Mice
  • Immunology
  • Humans
  • Hemophilia B
  • Gene Expression Regulation