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Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas.

Publication ,  Journal Article
Chang, L; El-Dairi, MA; Frempong, TA; Burner, EL; Bhatti, MT; Young, TL; Leigh, F
Published in: J AAPOS
December 2010

PURPOSE: Neurofibromatosis type 1 (NF1) is the most common neurocutaneous disorder, with an approximate incidence of 1 in 3,500. Optic pathway gliomas (OPGs) develop in 15% of individuals with NF1, commonly in childhood. OPGs are difficult to detect via a clinical inspection in children, often requiring magnetic resonance imaging (MRI). Given the significant visual risks associated with OPGs in NF1, there is a need for improved noninvasive techniques to diagnose OPGs in children; therefore, we studied optical coherence tomography (OCT) as a potential tool to assess optic nerve and retinal nerve fiber layer (RNFL) abnormalities. This prospective study was designed to evaluate OCT detection of RNFL loss from optic atrophy attributable to OPGs in a cohort of pediatric patients with NF1. METHODS: With the use of Stratus OCT, directed testing with the Fast Macular Thickness and Fast RNFL Thickness protocol scans were performed on 9 subjects with NF1 and known OPGs, 6 subjects with NF1 without OPGs, and 15 controls. RESULTS: NF1 subjects with OPGs had thinner RNFLs and macula when compared with age-matched controls and to NF1 subjects without OPGs. After applying the equivalence equation, the average RNFL thickness and macular volume in NF1 subjects without OPGs was equivalent to controls. CONCLUSIONS: Our study suggests that OCT can be used to detect RNFL thinning secondary to OPGs in NF1 subjects. This objective tool shows promise as a useful adjunct to routine clinical ophthalmologic evaluation in children with NF1.

Duke Scholars

Published In

J AAPOS

DOI

EISSN

1528-3933

Publication Date

December 2010

Volume

14

Issue

6

Start / End Page

511 / 517

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Prospective Studies
  • Optic Nerve Neoplasms
  • Optic Nerve
  • Ophthalmology & Optometry
  • Neurofibromatosis 1
  • Male
  • Macula Lutea
  • Incidence
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chang, L., El-Dairi, M. A., Frempong, T. A., Burner, E. L., Bhatti, M. T., Young, T. L., & Leigh, F. (2010). Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas. J AAPOS, 14(6), 511–517. https://doi.org/10.1016/j.jaapos.2010.08.014
Chang, Lan, Mays A. El-Dairi, Tamiesha A. Frempong, Erica L. Burner, M Tariq Bhatti, Terri L. Young, and Fawn Leigh. “Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas.J AAPOS 14, no. 6 (December 2010): 511–17. https://doi.org/10.1016/j.jaapos.2010.08.014.
Chang L, El-Dairi MA, Frempong TA, Burner EL, Bhatti MT, Young TL, et al. Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas. J AAPOS. 2010 Dec;14(6):511–7.
Chang, Lan, et al. “Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas.J AAPOS, vol. 14, no. 6, Dec. 2010, pp. 511–17. Pubmed, doi:10.1016/j.jaapos.2010.08.014.
Chang L, El-Dairi MA, Frempong TA, Burner EL, Bhatti MT, Young TL, Leigh F. Optical coherence tomography in the evaluation of neurofibromatosis type-1 subjects with optic pathway gliomas. J AAPOS. 2010 Dec;14(6):511–517.
Journal cover image

Published In

J AAPOS

DOI

EISSN

1528-3933

Publication Date

December 2010

Volume

14

Issue

6

Start / End Page

511 / 517

Location

United States

Related Subject Headings

  • Tomography, Optical Coherence
  • Prospective Studies
  • Optic Nerve Neoplasms
  • Optic Nerve
  • Ophthalmology & Optometry
  • Neurofibromatosis 1
  • Male
  • Macula Lutea
  • Incidence
  • Humans