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Initiation of human immunodeficiency virus type 1 (HIV-1) transcription is inhibited by noncytolytic CD8 suppression.

Publication ,  Journal Article
Overman, RG; Llorens, AL; Greenberg, ML; Garcia-Blanco, MA; Tomaras, GD
Published in: The open virology journal
January 2007

The replication of human immunodeficiency virus type 1 (HIV-1) can be inhibited by noncytolytic CD8(+) T cell mediated suppression, an immune response that specifically targets HIV-1 gene expression. Clinical studies demonstrate that this immune response may play an important role in the host defense against HIV infection. In this study, we examined the distinct steps in viral gene expression for inhibition by noncytolytic CD8(+) T cells. A primary HIV-1 infection system of CD4(+) enriched peripheral blood mononuclear cells was utilized to examine the HIV-1 life cycle as a relevant ex vivo system. Established CD8(+) T cell lines from two HIV(+) long-term nonprogressors were used to examine differences at the level of transcriptional initiation and elongation of the HIV genome. This infection system coupled with the results from real-time measurement of newly transcribed RNA transcripts determined that there was a significant decrease (5-8 fold) in short intracellular viral RNA transcripts. These data strongly favor a role for the initiation of virus transcription in noncytolytic CD8(+) T cell mediated suppression.

Duke Scholars

Published In

The open virology journal

DOI

EISSN

1874-3579

ISSN

1874-3579

Publication Date

January 2007

Volume

1

Start / End Page

1 / 7
 

Citation

APA
Chicago
ICMJE
MLA
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Overman, R. G., Llorens, A. L., Greenberg, M. L., Garcia-Blanco, M. A., & Tomaras, G. D. (2007). Initiation of human immunodeficiency virus type 1 (HIV-1) transcription is inhibited by noncytolytic CD8 suppression. The Open Virology Journal, 1, 1–7. https://doi.org/10.2174/1874357900701010001
Overman, R Glenn, Anthony L. Llorens, Michael L. Greenberg, Mariano A. Garcia-Blanco, and Georgia D. Tomaras. “Initiation of human immunodeficiency virus type 1 (HIV-1) transcription is inhibited by noncytolytic CD8 suppression.The Open Virology Journal 1 (January 2007): 1–7. https://doi.org/10.2174/1874357900701010001.
Overman RG, Llorens AL, Greenberg ML, Garcia-Blanco MA, Tomaras GD. Initiation of human immunodeficiency virus type 1 (HIV-1) transcription is inhibited by noncytolytic CD8 suppression. The open virology journal. 2007 Jan;1:1–7.
Overman, R. Glenn, et al. “Initiation of human immunodeficiency virus type 1 (HIV-1) transcription is inhibited by noncytolytic CD8 suppression.The Open Virology Journal, vol. 1, Jan. 2007, pp. 1–7. Epmc, doi:10.2174/1874357900701010001.
Overman RG, Llorens AL, Greenberg ML, Garcia-Blanco MA, Tomaras GD. Initiation of human immunodeficiency virus type 1 (HIV-1) transcription is inhibited by noncytolytic CD8 suppression. The open virology journal. 2007 Jan;1:1–7.

Published In

The open virology journal

DOI

EISSN

1874-3579

ISSN

1874-3579

Publication Date

January 2007

Volume

1

Start / End Page

1 / 7