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New therapeutic possibilities for vein graft disease in the post-edifoligide era.

Publication ,  Journal Article
Cai, X; Freedman, NJ
Published in: Future Cardiol
July 2006

Vein graft neointimal hyperplasia involves proliferation and migration of vascular smooth muscle cells into the vessel intima, and ultimately engenders accelerated atherosclerosis and vein graft failure. Since a myriad of stimuli provoke smooth muscle cell proliferation, molecular therapies for vein graft disease have targeted mechanisms fundamental to all cell proliferation - the 'cell-cycle' machinery. Preclinically, the most successful of these therapies has been edifoligide (E2F decoy), a double-stranded oligodeoxynucleotide that binds to the transcription factor known as E2F. Recently, PRoject of Ex vivo vein GRaft Engineering via Transfection (PREVENT) III and IV demonstrated that edifoligide failed to benefit human vein grafts employed to treat lower-extremity ischemia and coronary heart disease, respectively. The clinical failure of edifoligide calls into question previous models of vein graft disease and lends credence to recent animal studies demonstrating that vein graft arterialization substantially involves the immigration into the vein graft of a variety of vascular progenitor cells. Future vein graft disease therapies will likely target not only proliferation of graft-intrinsic cells, but also immigration of graft-extrinsic cells.

Duke Scholars

Published In

Future Cardiol

DOI

EISSN

1744-8298

Publication Date

July 2006

Volume

2

Issue

4

Start / End Page

493 / 501

Location

England

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Cai, X., & Freedman, N. J. (2006). New therapeutic possibilities for vein graft disease in the post-edifoligide era. Future Cardiol, 2(4), 493–501. https://doi.org/10.2217/14796678.2.4.493
Cai, Xinjiang, and Neil J. Freedman. “New therapeutic possibilities for vein graft disease in the post-edifoligide era.Future Cardiol 2, no. 4 (July 2006): 493–501. https://doi.org/10.2217/14796678.2.4.493.
Cai X, Freedman NJ. New therapeutic possibilities for vein graft disease in the post-edifoligide era. Future Cardiol. 2006 Jul;2(4):493–501.
Cai, Xinjiang, and Neil J. Freedman. “New therapeutic possibilities for vein graft disease in the post-edifoligide era.Future Cardiol, vol. 2, no. 4, July 2006, pp. 493–501. Pubmed, doi:10.2217/14796678.2.4.493.
Cai X, Freedman NJ. New therapeutic possibilities for vein graft disease in the post-edifoligide era. Future Cardiol. 2006 Jul;2(4):493–501.
Journal cover image

Published In

Future Cardiol

DOI

EISSN

1744-8298

Publication Date

July 2006

Volume

2

Issue

4

Start / End Page

493 / 501

Location

England

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology